A role for Streptococcus pneumoniae in virus-associated pneumonia

• Type of Material: Article
• Authors: Shabir A. Madhi, University of the Witwatersrand; Keith Klugman, Emory University
• Language: English
• Date: 2004-08-01
• Publisher: NATURE PUBLISHING GROUP
• Publication Version: Final Published Version
• Copyright Statement: © Nature Publishing Group 2004
• Final Published Version (URL): http://dx.doi.org/10.1038/nm1077
• Title of Journal or Parent Work: NATURE MEDICINE
• Volume: 10
• Issue: 8
• Start Page: 811
• End Page: 813
• Grant/Funding Information: Vaccine trial was funded by Wyeth.
• Keywords: IMMUNOGENICITY; IMPACT; Biochemistry & Molecular Biology; TYPE-1; Science & Technology; PNEUMOCOCCAL CONJUGATE VACCINE; DISEASE; Research & Experimental Medicine; Life Sciences & Biomedicine; Medicine, Research & Experimental; RESPIRATORY-TRACT INFECTIONS; AFRICAN CHILDREN; Cell Biology; BACTERIAL
• Research Categories: Health Sciences, Immunology; Biology, Cell

Abstract

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.