NSAID-ERD Syndrome: the New Hope from Prevention, Early Diagnosis, and New Therapeutic Targets

• Type of Material: Article
• Authors: Tanya M Laidlaw, Harvard Medical School; Joshua Levy, Emory University
• Language: English
• Date: 2020-03-14
• Publisher: CURRENT MEDICINE GROUP
• Publication Version: Final Published Version
• Copyright Statement: © 2020, Springer Science Business Media, LLC, part of Springer Nature
• Final Published Version (URL): http://dx.doi.org/10.1007/s11882-020-00905-9
• Title of Journal or Parent Work: CURRENT ALLERGY AND ASTHMA REPORTS
• Volume: 20
• Issue: 4
• Start Page: 10
• End Page: 10
• Keywords: NASAL POLYPS; Science & Technology; Asthma; EXACERBATED RESPIRATORY-DISEASE; AERD; DRIVEN; ENDOSCOPIC SINUS SURGERY; Life Sciences & Biomedicine; Immunology; ASPIRIN DESENSITIZATION; Allergy; ASTHMATIC-PATIENTS; NSAID-ERD; OUTCOMES; CHRONIC RHINOSINUSITIS; NSAIDs; MEPOLIZUMAB; Aspirin; Nasal polyps; LONG-TERM TREATMENT

Abstract

Purpose of Review: This review summarizes the latest information on the appropriate identification, evaluation, and treatment of patients with nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NSAID-ERD), also known as aspirin-exacerbated respiratory disease (AERD). Within the framework of our understanding of the underlying pathophysiology of NSAID-ERD, we also provide an update regarding new surgical techniques and newly available or upcoming medical therapies that may benefit these patients. Recent Findings: There have been considerable developments regarding recommendations for both the extent and timing of sinus surgery for NSAID-ERD. The last few years have also given us several new biologic medications that warrant consideration in the treatment of patients with recalcitrant NSAID-ERD. Further clinical trials are underway to investigate additional medications that may decrease the type 2 inflammation that dominates this disease. Summary: Despite the severe lower respiratory inflammation and recurrent nature of the nasal polyps in patients with NSAID-ERD, significant recent advances now afford much-improved quality of life for these patients. Careful collaboration between Allergy/Immunology and Rhinology specialists is imperative to ensure proper treatment of patients with NSAID-ERD.