Axis I psychiatric diagnoses in adolescents and young adults with 22q11 deletion syndrome

• Type of Material: Article
• Authors: Opal Ousley, Emory University; E. Smearman, Emory University; Samuel Fernandez-Carriba, Emory University; K.A. Rockers, Emory University; K. Coleman, Emory University; Joseph F Cubells, Emory University
• Language: English
• Date: 2013-09-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 Elsevier Masson SAS.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.eurpsy.2013.06.002
• Title of Journal or Parent Work: European Psychiatry
• ISSN: 0924-9338
• Volume: 28
• Issue: 7
• Start Page: 417
• End Page: 422
• Grant/Funding Information: Grant support: Robert W. Woodruff Fund (J.F. Cubells, O.Y. Ousley), NARSAD (O.Y. Ousley), the Autism Foundation of Georgia (J.F. Cubells), NIH Medical Scientist Training grant T32 GM008169 (E. Smearman), and the Burroughs Wellcome Fund (Grant number 008188; E. Smearman).
• Keywords: SCHIZOPHRENIA; PRODROMAL SYNDROMES; Life Sciences & Biomedicine; Anxiety disorders; INTERRATER RELIABILITY; Schizophrenia and psychosis; Genetics; DE-NOVO; INTERVIEW; Psychiatry; ONSET; SYMPTOMS; Affective disorders; AUTISTIC SPECTRUM DISORDERS; CARDIO-FACIAL SYNDROME; Science & Technology; Autism; PREDICTIVE-VALIDITY
• Research Categories: Psychology, Behavioral; Health Sciences, Public Health; Biology, Genetics

Abstract

Background: 22q11.2 deletion syndrome (22q11DS) associates with schizophrenia spectrum disorders (SSDs), autism spectrum disorders (ASDs), and other psychiatric disorders, but co-occurrence of diagnoses are not well described. Methods: We evaluated the co-occurrence of SSDs, ASDs and other axis I psychiatric diagnoses in 31 adolescents and adults with 22q11DS, assessing ASDs using either stringent Collaborative Program for Excellence in Autism (ASD-CPEA) criteria, or less stringent DSM-IV criteria alone (ASD-DSM-IV). Results: Ten (32%) individuals met criteria for an SSD, five (16%) for ASD-CPEA, and five others (16%) for ASD-DSM-IV. Of those with ASD-CPEA, one (20%) met SSD criteria. Of those with ASD-DSM-IV, four (80%) met SSD criteria. Depressive disorders (8 individuals; 26%) and anxiety disorders (7; 23%) sometimes co-occurred with SSDs and ASDs. SSDs, ASDs, and anxiety occurred predominantly among males and depression predominantly among females. Conclusions: Individuals with 22q11DS can manifest SSDs in the presence or absence of ASDs and other axis I diagnoses. The results suggest that standard clinical care should include childhood screening for ASDs, and later periodic screening for all axis I diagnoses. © 2013 Elsevier Masson SAS.