A systematic review of interventions to promote HPV vaccination globally

• Type of Material: Article
• Authors: Ngoc-Cam Escoffery, Emory University; Courtney Petagna, Emory University; Christine Agnone, Emory University; Stephen Perez, Emory University; Lindsay B Saber, Emory University; Grace Ryan, Univ Massachusetts; Meena Dhir, Emory University; Swathi Sekar, Emory University; Katherine Yeager, Emory University; Caitlin B Biddell, University of North Carolina Chapel Hill; Purnima Madhivanan, University of Arizona; Stephanie Lee, Emory University; Amanda English, University of North Texas Health Science Center; Lara Savas, University of Texas Health Science Center at Houston; Eliza Daly, University of Iowa; Thuy Vu, University of Washington; Maria Fernandez, University of Texas Health Science Center at Houston
• Language: English
• Date: 2023-06-29
• Publisher: BMC
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2023
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1186/s12889-023-15876-5
• Title of Journal or Parent Work: BMC PUBLIC HEALTH
• Volume: 23
• Issue: 1
• Start Page: 1262
• End Page: 1262
• Grant/Funding Information: This study was supported by Centers for Disease Control and Prevention, SIP 19–005 Cancer Prevention and Control Research Network, U48DP006377, U48DP006389, U48DP006400, U48DP006413, U48DP006408 and U48DP006398. CBB was supported by a NIH Cancer Care Quality Training Program grant, UNC-CH, Grant No. T32-CA-116339. GR was supported by the National Cancer Institute Grant No. T32-CA-172009. PM was supported by P30CA023074-41. The funders had no role in the study design, data collection, analysis, and interpretation of data and in writing the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the CDC or NIH.
• Keywords: IMPACT; Adolescent; Young adults; BRIEF EDUCATIONAL INTERVENTION; Life Sciences & Biomedicine; Public, Environmental & Occupational Health; Interventions; Vaccination; CERVICAL-CANCER; HEALTH; Health promotion; Science & Technology; INCREASE KNOWLEDGE; ADOLESCENTS; ADVISORY-COMMITTEE; PROVIDER COMMUNICATION; HPV vaccination; HUMAN-PAPILLOMAVIRUS VACCINATION; UNITED-STATES
• Research Categories: Health Sciences, Nursing; Health Sciences, Public Health

Abstract

Background: Despite the human papillomavirus (HPV) vaccine being a safe, effective cancer prevention method, its uptake is suboptimal in the United States (U.S.). Previous research has found a variety of intervention strategies (environmental and behavioral) to increase its uptake. The purpose of the study is to systematically review the literature on interventions that promote HPV vaccination from 2015 to 2020. Methods: We updated a systematic review of interventions to promote HPV vaccine uptake globally. We ran keyword searches in six bibliographic databases. Target audience, design, level of intervention, components and outcomes were abstracted from the full-text articles in Excel databases. Results: Of the 79 articles, most were conducted in the U.S. (72.2%) and in clinical (40.5%) or school settings (32.9%), and were directed at a single level (76.3%) of the socio-ecological model. Related to the intervention type, most were informational (n = 25, 31.6%) or patient-targeted decision support (n = 23, 29.1%). About 24% were multi-level interventions, with 16 (88.9%) combining two levels. Twenty-seven (33.8%) reported using theory in intervention development. Of those reporting HPV vaccine outcomes, post-intervention vaccine initiation ranged from 5% to 99.2%, while series completion ranged from 6.8% to 93.0%. Facilitators to implementation were the use of patient navigators and user-friendly resources, while barriers included costs, time to implement and difficulties of integrating interventions into the organizational workflow. Conclusions: There is a strong need to expand the implementation of HPV-vaccine promotion interventions beyond education alone and at a single level of intervention. Development and evaluation of effective strategies and multi-level interventions may increase the uptake of the HPV vaccine among adolescents and young adults.