Risk factors for pediatric invasive group A streptococcal disease

• Type of Material: Article
• Authors: Stephanie H. Factor, New York City Department of Health and Mental Hygiene; Orin S. Levine, Centers for Disease Control and Prevention; Lee H. Harrison, Johns Hopkins University; Monica Farley, Emory University; Allison McGeer, Mount Sinai Hospital; Tami Skoff, Centers for Disease Control and Prevention; Carolyn Wright, Centers for Disease Control and Prevention; Benjamin Schwartz, Centers for Disease Control and Prevention; Anne Schuchat, Emory University
• Language: English
• Date: 2005-07-01
• Publisher: CENTER DISEASE CONTROL
• Publication Version: Final Published Version
• Copyright Statement: All material published in Emerging Infectious Diseases is in the public domain and may be used and reprinted without special permission; proper citation, however, is required.
• License: Creative Commons Universal : Public Domain Dedication
• Final Published Version (URL): http://dx.doi.org/10.3201/eid1107.040900
• Title of Journal or Parent Work: EMERGING INFECTIOUS DISEASES
• Volume: 11
• Issue: 7
• Start Page: 1062
• End Page: 1066
• Grant/Funding Information: Funding for this study came from the Emerging Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
• Keywords: Science & Technology; BACTEREMIA; Infectious Diseases; Life Sciences & Biomedicine; TOXIC SHOCK SYNDROME; CHILDREN; HAEMOPHILUS-INFLUENZAE; PRIMARY VARICELLA; ADULTS; INFECTIONS; POPULATION-BASED ASSESSMENT; NORTH-CAROLINA; PNEUMOCOCCAL DISEASE; Immunology
• Research Categories: Health Sciences, Immunology; Biology, Virology

Abstract

Invasive group A Streptococcus (GAS) infections can be fatal and can occur in healthy children. A case-control study identified factors associated with pediatric disease. Case-patients were identified when Streptococcus pyogenes was isolated from a normally sterile site, and matched controls (≥2) were identified by using sequential-digit dialing. All participants were noninstitutionalized surveillance-area residents <18 years of age. Conditional regression identified factors associated with invasive disease: other children living in the home (odds ratio [OR] = 16.85, p = 0.0002) and new use of nonsteroidal antiinflammatory drugs (OR = 10.64, p = 0.005) were associated with increased risk. More rooms in the home (OR = 0.67, p = 0.03) and household member(s) with runny nose (OR = 0.09, p = 0.002) were associated with decreased risk. Among children, household-level characteristics that influence exposure to GAS most affect development of invasive disease.