Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

• Type of Material: Article
• Authors: Diego S. Dumani, Emory University; Jason R. Cook, NanoHybrids, Inc.; Kelsey P. Kubelick, Emory University; Jeffrey J. Luci, University of Texas at Austin; Stanislav Emelianov, Emory University
• Language: English
• Date: 2020-02-01
• Publisher: Dove Medical Press
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 Elsevier Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.nano.2019.102138
• Title of Journal or Parent Work: Nanomedicine: Nanotechnology, Biology, and Medicine
• Volume: 24
• Start Page: 102138
• End Page: 102138
• Grant/Funding Information: This work was supported in part the Breast Cancer Research Foundation [grant number BCRF-19-043]; and National Institutes of Health [grant numbers EB008101, CA158598, CA149740].; This work was performed in part at the Georgia Tech Institute for Electronics and Nanotechnology, a member of the National Nanotechnology Coordinated Infrastructure, which is supported by the National Science Foundation (Grant ECCS-1542174).
• Keywords: Spectrometry, X-Ray Emission; Animals; Female; Metal Nanoparticles; Microscopy, Electron, Transmission; Contrast Media; Photoacoustic Techniques; Nanoparticles; Mice; Magnetic Resonance Imaging; Photomagnetic; Magnetic nanoparticle; Prussian blue; Ferric Compounds; Ferrocyanides; Size control; Imaging
• Research Categories: Biology, Neuroscience; Computer Science; Engineering, Biomedical

Abstract

Nanoparticles play an important role in biomedicine. We have developed a method for size-controlled synthesis of photomagnetic Prussian blue nanocubes (PBNCs) using superparamagnetic iron oxide nanoparticles (SPIONs) as precursors. The developed PBNCs have magnetic and optical properties desired in many biomedical diagnostic and therapeutic applications. Specifically, the size-tunable photomagnetic PBNCs exhibit high magnetic saturation, strong optical absorption with a peak at approximately 700 nm, and superior photostability. Our studies demonstrate that PBNCs can be used as MRI and photoacoustic imaging contrast agents in vivo. We also showed the utility of PBNCs for labeling and magnetic manipulation of cells. Dual magnetic and optical properties, together with excellent biocompatibility, render PBNCs an attractive contrast agent for both diagnostic and therapeutic applications. The use SPIONs as precursors for PBNCs provides flexibility and allows researchers to design theranostic agents according to required particle size, optical, and magnetic properties.