Residual Disease and HPV Persistence after Cryotherapy for Cervical Intraepithelial Neoplasia Grade 2/3 in HIV-Positive Women in Kenya

• Type of Material: Article
• Authors: Hugo De Vuyst, International Agency for Research on Cancer; Nelly R. Mugo, Kenyatta National Hospital; Silvia Franceschi, International Agency for Research on Cancer; Kevin McKenzie, University of Washington; Vanessa Tenet, International Agency for Research on Cancer; Julia Njoroge, University of Washington; Farzana S. Rana, Aga Khan University Hospital; Samah R. Sakr, Coptic Hospital; Peter J. F. Snijders, Vrije Universiteit Amsterdam; Michael Chung, Emory University
• Language: English
• Date: 2014-10-24
• Publisher: PUBLIC LIBRARY SCIENCE
• Publication Version: Final Published Version
• Copyright Statement: © 2014 De Vuyst et al
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1371/journal.pone.0111037
• Title of Journal or Parent Work: PLOS ONE
• Volume: 9
• Issue: 10
• Start Page: e111037
• End Page: e111037
• Grant/Funding Information: This work was funded by the Washington Global Health Alliance, the National Institutes of Health (grant number 5K23AI065222-04), the Fondation de France (grant number 00016673), and the Bill & Melinda Gates Foundation (grant number 35537). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• Keywords: INFECTED WOMEN; Multidisciplinary Sciences; HIGH-RISK; HUMAN-IMMUNODEFICIENCY-VIRUS; Science & Technology; ANTIRETROVIRAL THERAPY; FOLLOW-UP; RECURRENCE; HUMAN-PAPILLOMAVIRUS; RESIDUAL/RECURRENT DISEASE; Science & Technology - Other Topics; CYTOLOGY; DYSPLASIA
• Research Categories: Health Sciences, Obstetrics and Gynecology; Biology, Virology

Abstract

Methods: 79 HIV-positive women received cryotherapy for CIN2/3 in Nairobi, Kenya, and underwent conventional cytology 6 months later. Biopsies were performed on high grade cytological lesions and hrHPV was assessed before (cervical cells and biopsy) and after cryotherapy (cells).