Improved Biochemical Strategies for Targeted Delivery of Taxoids

• Type of Material: Article
• Authors: Thota Ganesh, Emory University
• Language: English
• Date: 2007-06-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2007 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.bmc.2007.03.041
• Title of Journal or Parent Work: Bioorganic and Medicinal Chemistry
• ISSN: 0968-0896
• Volume: 15
• Issue: 11
• Start Page: 3597
• End Page: 3623
• Grant/Funding Information: Author is grateful to Dr. Dennis C. Liotta, Emory University for financial support.
• Keywords: TPT; antibody; drug targeting; ADEPT; colloidal gold nanoparticles; drug conjugate; cancer cells; prodrug; receptor; Taxoid
• Research Categories: Health Sciences, Oncology; Chemistry, General

Abstract

Paclitaxel (Taxol ®) and docetaxel (Taxotere ®) are very important anti-tumor drugs in clinical use for cancer. However, their clinical utility is limited due to systemic toxicity, low solubility and inactivity against drug resistant tumors. To improve chemotherapeutic levels of these drugs, it would be highly desirable to design strategies which bypass the above limitations. In this respect various prodrug and drug targeting strategies have been envisioned either to improve oral bioavailability or tumor specific delivery of taxoids. Abnormal properties of cancer cells with respect to normal cells have guided in designing of these protocols. This review article records the designed biochemical strategies and their biological efficacies as potential taxoid chemotherapeutics.