The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol

• Type of Material: Article
• Authors: Daniel Woo, University of Cincinnati; Jonathan Rosand, Harvard University; Chelsea Kidwell, Georgetown University; Jacob L. McCauley, University of Miami; Jennifer Osborne, University of Cincinnati; Mark W. Brown, Wake Forest University; Sandra E. West, University of Miami; Eric W. Rademacher, University of Cincinnati; Salina Waddy, National Institute of Neurological Disorders and Stroke; Jamie N. Roberts, National Institute of Neurological Disorders and Stroke; Sebastian Koch, University of Miami; Nicole R. Gonzales, University of Texas Houston; Gene Sung, University of Southern California; Steen J. Kittner, University of Maryland; Lee Birnbaum, University of Texas San Antonio; Michael Frankel, Emory University; Fernando Daniel Testai, University of Illinois; Christiana E. Hall, University of Texas Dallas; Mitchell S. B. Elkind, Columbia University; Matthew Flaherty, Emory University; Bruce Coull, University of Arizona; Ji Y. Chong, St. Lukes Roosevelt Hospital; Tanya Warwick, University of California San Francisco; Marc Malkoff, University of New Mexico; Michael L. James, Duke University; Latisha K. Ali, University of California Los Angeles; Bradford B. Worrall, University of Virginia; Floyd Jones, University of Texas San Antonio; Tiffany Watson, University of Maryland; Anne Leonard, University of Texas San Antonio; Rebecca Martinez, University of Texas Houston; Ralph I. Sacco, University of Miami; Carl D. Langefeld, Wake Forest University
• Language: English
• Date: 2013-10-01
• Publisher: American Heart Association
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2013 American Heart Association, Inc.
• Final Published Version (URL): http://dx.doi.org/10.1161/STROKEAHA.113.002332
• Title of Journal or Parent Work: Stroke
• ISSN: 0039-2499
• Volume: 44
• Issue: 10
• Start Page: E120
• End Page: E125
• Grant/Funding Information: This study is supported by a grant from the National Institute of Neurological Disorders and Stroke (NINDS: U-01-NS069763).
• Keywords: Peripheral Vascular Disease; Cardiovascular System & Cardiology; RISK; risk factors; minority groups; EUROQOL; Neurosciences & Neurology; Life Sciences & Biomedicine; PANEL; STROKE; BLACKS; hypertension; QUALITY-OF-LIFE; WHITES; COGNITIVE STATUS; genetics; stroke; ADMIXTURE; genomics; Science & Technology; Clinical Neurology; cerebral hemorrhage
• Research Categories: Biology, Genetics; Biology, Neuroscience

Abstract

Background and Purpose-Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods-The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case- control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results-As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions-The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.