Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature

• Type of Material: Article
• Authors: Reut Gurion, Rainbow Babies and Children’s Hospital; Vin Tangpricha, Emory University; Eric Yow, Duke Clinical Research Institute; Laura E. Schanberg, Duke University; Grace A. McComsey, Rainbow Babies and Children’s Hospital; Angela Byun Robinson, Rainbow Babies and Children’s Hospital
• Language: English
• Date: 2015-04-23
• Publisher: BioMed Central
• Publication Version: Final Published Version
• Copyright Statement: © 2015 Gurion et al.; licensee BioMed Central. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• Final Published Version (URL): http://dx.doi.org/10.1186/s12969-015-0008-x
• Title of Journal or Parent Work: Pediatric Rheumatology
• ISSN: 1546-0096
• Volume: 13
• Issue: 1
• Start Page: 13
• End Page: 13
• Grant/Funding Information: Secondary analysis were supported by the Rainbow Babies and Children’s Hospital Pediatrics Pilot Award, and the NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases contract 5P30-AR-047363-12).; APPLE was supported by the NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases contract N01-AR-2-2265), the Edna and Fred L. Mandel Jr. Center for Hypertension and Atherosclerosis, and Pfizer, which provided atorvastatin and matching placebo.
• Keywords: Science & Technology; Systemic lupus erythematosus; CALVE-PERTHES-DISEASE; SICKLE-CELL DISEASE; Rheumatology; VITAMIN-D DEFICIENCY; CAPITAL FEMORAL EPIPHYSIS; IDIOPATHIC OSTEONECROSIS; Life Sciences & Biomedicine; ANTIPHOSPHOLIPID ANTIBODIES; Pediatrics; Avascular necrosis; RISK-FACTORS
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities.