Host Defense Peptides from Asian Frogs as Potential Clinical Therapies.

• Type of Material: Article
• Authors: Vineeth T.V. Kumar, Rajiv Gandhi Centre for Biotechnology (RGCB); David Holthausen, Emory University; Joshy Jacob, Emory University; Sanil George, Rajiv Gandhi Centre for Biotechnology (RGCB)
• Language: English
• Date: 2015
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2015 by the authors; licensee MDPI, Basel, Switzerland.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/antibiotics4020136
• Title of Journal or Parent Work: Antibiotics
• ISSN: 2079-6382
• Volume: 4
• Issue: 2
• Start Page: 136
• End Page: 159
• Grant/Funding Information: Vineeth T.V. Kumar and Sanil George are thankful to Kerala State Council for Science, Technology and Environment (KSCSTE), Govt. of Kerala, India for financial assistance. Grant No: (No.006/SRSLS/2011/CSTE).
• Keywords: Multi-drug resistance; Asian frog; Anti-microbial peptides; Host defense peptides
• Research Categories: Health Sciences, Immunology; Biology, Microbiology

Abstract

Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological membranes, and their peculiar mode of action. Even though HDPs from 60 Asian frog species belonging to 15 genera have been characterized, research into these peptides is at a very early stage. The purpose of this review is to showcase the status of peptide research in Asia. Here we provide a summary of HDPs from Asian frogs.