Sustainable production of orphan radionuclides at Wisconsin

• Type of Material: Article
• Authors: R. J. Nickles, University of Wisconsin; M. A. Avila-Rodriguez, University of Wisconsin; Jonathon A Nye, Emory University; E. N. Houser, University of Wisconsin; R. G. Selwyn, University of Wisconsin; M. J. Schueller, Brookhaven National Laboratory; B. T. Christian, University of Wisconsin; M. Jensen, University of Wisconsin
• Language: English
• Date: 2008-06-01
• Publisher: Edizioni Minerva Medica
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright © 2008 EDIZIONI MINERVA MEDICA
• Final Published Version (URL): https://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2008N03A0235
• Title of Journal or Parent Work: Quarterly Journal of Nuclear Medicine and Molecular Imaging
• ISSN: 1824-4785
• Volume: 52
• Issue: 2
• Start Page: 134
• End Page: 139
• Grant/Funding Information: This study was supported by grants DOE DE-FG01-01NE23052 and NIH/NCI 5 T32 CA09206.
• Keywords: Life Sciences & Biomedicine; CYCLOTRON; TARGET; radionuclides; Radiology, Nuclear Medicine & Medical Imaging; Science & Technology; I-124; tomography, emission computed; radiopharmaceuticals; Y-90
• Research Categories: Physics, Nuclear

Abstract

Over a hundred proton-induced reactions have been studied at the University of Wisconsin Medical Physics department since the installation of the first CTI RDS 112 in 1985. The focus has been to measure thick target yields at 11 MeV, in an effort to concentrate on the practical production of positron emitting radionuclides that have favorable decay characteristics, high yields and the potential for labeling pivotal biological tracers. This review covers our recent advances to scale-up the production of the heavy halogens and transition metals as feed-stock for non-conventional PET tracers that are currently attracting increased attention in oncology.