Two cases of fungal keratitis caused by Metarhizium anisopliae

• Type of Material: Article
• Authors: Abigail L. Goodman, Emory University; Shawn R. Lockhart, Centers for Disease Control and Prevention; Colleen B. Lysen, Centers for Disease Control and Prevention; Lars Westblade, Emory University; Carey-Ann D. Burnham, Washington University School of Medicine, St. Louis; Eileen Burd, Emory University
• Language: English
• Date: 2018-09-01
• Publisher: Elsevier: Creative Commons
• Publication Version: Final Published Version
• Copyright Statement: © 2018 The Authors
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.mmcr.2018.03.003
• Title of Journal or Parent Work: Medical Mycology Case Reports
• ISSN: 2211-7539
• Volume: 21
• Start Page: 8
• End Page: 11
• Keywords: Keratomycosis; Antifungal susceptibility; Metarhizium; Fungal keratitis
• Research Categories: Health Sciences, Immunology; Health Sciences, Pathology

Abstract

We present two cases of keratitis due to Metarhizium anisopliae in geographically separated areas of the United States. The isolates were microscopically similar but morphologically different and were identified by ribosomal DNA sequencing. Both isolates had low minimum inhibitory concentration (MIC) values to caspofungin and micafungin, but high MIC values to amphotericin B. The morphologic and antifungal susceptibility differences between the two isolates indicate possible polyphylogeny of the group.