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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

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  • 05/15/2025
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Authors
    KL Monda, University of North Carolina at Chapel HillGK Chen, University of Southern CaliforniaC Palmer, Broad Institute of Harvard & MITTL Edwards, Vanderbilt UniversityLA Lange, University of North CarolinaMCY Ng, Wake Forest UniversityAA Adeyemo, NHGRIMA Allison, University of California San DiegoLF Bielak, University of MichiganG Chen, NHGRIM Graff, University of North CarolinaMR Irvin, University of Alabama BirminghamSK Rhie, University of Southern CaliforniaG Li, University of WashingtonY Liu, Wake Forest UniversityY Liu, University of North CarolinaY Lu, Icahn School of Medicine at Mt SinaiMA Nalls, NIAYan Sun, Emory UniversityMK Wojczynski, Washington UniversityLR Yanek, Johns Hopkins UniversityMC Aldrich, Vanderbilt UniversityA Ademola, Washington UnivCI Amos, University of Texas MD Anderson Cancer CenterEV Bandera, Cancer Institute New JerseyCH Bock, Wayne State UniversityA Britton, NIAU Broeckel, Medical College of WisconsinQ Cai, Vanderbilt UniversityNE Caporaso, NCICS Carlson, Fred Hutchinson Cancer Research CenterJ Carpten, Translational Genomics Research InstituteG Casey, University of Southern CaliforniaW-M Chen, University of VirginiaF Chen, University of VirginiaY-DI Chen, Cedars Sinai Med CenterCWK Chiang, Harvard UniversityGA Coetzee, University of Southern CaliforniaE Demerath, University of MinnesotaSL Deming-Halverson, Vanderbilt UniversityRW Driver, American Cancer SocietyP Dubbert, South Cent VA Mental Illness Res & Clin CtrMF Feitosa, Washington UniversityY Feng, University of Southern CaliforniaBI Freedman, Wake Forest UniversityEM Gillanders, NCIO Gottesman, Icahn Sch Med Mt SinaiX Guo, Cedars Sinai Medical CenterT Haritunians, Cedars Sinai Medical CenterT Harris, NIACC Harris, NCIAJM Hennis, SUNY Stony BrookDG Hernandez, NIALH McNeill, University of Texas MD Anderson Cancer CenterTD Howard, Wake Forest UniversityBV Howard, MedStar Health Research InstituteVJ Howard, University of Alabama BirminghamKC Johnson, University of TennesseeSJ Kang, Suny Downstate Medical CenterBJ Keating, University of PennsylvaniaS Kolb, Fred Hutchinson Cancer Research CenterLH Kuller, University of PittsburghA Kutlar, Georgia Health Sciences UniversityCD Langefeld, Wake Forest UniversityG Lettre, University of MontrealK Lohman, Wake Forest UniversityV Lotay, Icahn School of Medicine at Mt SinaiH Lyon, Harvard Medical SchoolJE Manson, Harvard UniversityW Maixner, University of North CarolinaYA Meng, Broad Institute of MIT and HarvardKR Monroe, University of Southern CaliforniaI Morhason-Bello, Broad Institute of MIT and HarvardAB Murphy, Northwestern UniversityJC Mychaleckyj, University of VirginiaR Nadukuru, Icahn School of Medicine at Mt SinaiKL Nathanson, University of PennsylvaniaU Nayak, University of VirginiaA N'Diaye, Université de MontréalB Nemesure, SUNY Stony BrookS-Y Wu, SUNY Stony BrookMC Leske, SUNY Stony BrookC Neslund-Dudas, Henry Ford HospitalM Neuhouser, Fred Hutchinson Cancer Research CenterS Nyante, University of North CarolinaH Ochs-Balcom, SUNY BuffaloA Ogunniyi, University of IbadanTO Ogundiran, University of IbadanO Ojengbede, Broad Institute of MIT and HarvardOI Olopade, University of ChicagoJR Palmer, Boston UniversityEA Ruiz-Narvaez, Boston UniversityND Palmer, Wake Forest UniversityMF Press, University of Southern CaliforniaE Rampersaud, University of MiamiLJ Rasmussen-Torvik, Northwestern UniversityJL Rodriguez-Gil, University of MiamiB Salako, University of IbadanEE Schadt, Icahn School of Medicine at Mt SinaiAG Schwartz, Wayne State UniversityDA Shriner, Wake Forest UniversityD Siscovick, University of WashingtonSB Smith, University of North CarolinaS Wassertheil-Smoller, Albert Einstein College of MedicineEK Speliotes, University of MichiganMR Spitz, Baylor College of MedicineL Sucheston, Roswell Park Cancer InstituteHerman Taylor, Emory UniversityBO Tayo, Loyola University ChicagoMA Tucker, NCIDJ Van Den Berg, University of Southern CaliforniaDRV Edwards, Vanderbilt UniversityZ Wang, NCIJK Wiencke, University of California San FranciscoTW Winkler, Icahn School of Medicine at Mt SinaiJS Witte, University of California San FranciscoM Wrensch, University of California San FranciscoX Wu, University of Texas MD Anderson Cancer CenterJJ Yang, Henry Ford HospitalAM Levin, Henry Ford HospitalTR Young, Broad Institute of MIT and HarvardNA Zakai, University of VermontM Cushman, University of VermontKA Zanetti, NCIJH Zhao, Addenbrookes HospitalW Zhao, University of MichiganY Zheng, University of ChicagoJ Zhou, Wake Forest UniversityRG Ziegler, NCIJM Zmuda, University of PittsburghJK Fernandes, Medical University of South CarolinaGS Gilkeson, Medical University of South CarolinaDL Kamen, Medical University of South CarolinaKJ Hunt, Medical University of South CarolinaIJ Spruill, Medical University of South CarolinaCB Ambrosone, Roswell Park Cancer InstituteS Ambs, NCIDK Arnett, University of Alabama BirminghamL Atwood, Boston UniversityDM Becker, Johns Hopkins UniversitySI Berndt, NCIL Bernstein, City Hope National Medical CenterWJ Blot, Vanderbilt UniversityIB Borecki, Washington UniversityEP Bottinger, Icahn School of Medicine at Mt SinaiDW Bowden, Wake Forest UniversityGreg Burke, Emory UniversitySJ Chanock, NCIRS Cooper, Loyola University ChicagoJ Ding, Wake Forest UniversityD Duggan, Translational Genomics Research InstituteMK Evans, NIAC Fox, NHLBIWT Garvey, University of Alabama BirminghamJP Bradfield, Childrens Hospital of PhiladelphiaH Hakonarson, Childrens Hospital of PhiladelphiaSFA Grant, Childrens Hospital of PhiladelphiaA Hsing, Cancer Prevention Institute of CaliforniaL Chu, Stanford UniversityJJ Hu, University of MiamiD Huo, University of ChicagoSA Ingles, University of Southern CaliforniaEM John, Cancer Prevention Institute of CaliforniaJM Jordan, University of North CarolinaEK Kabagambe, Vanderbilt UniversitySLR Kardia, University of MichiganRA Kittles, University of ChicagoPJ Goodman, SWOG Statistical CenterEA Klein, Cleveland ClinicLN Kolonel, University of HawaiiL Le Marchand, University of HawaiiS Liu, University of California Los AngelesB McKnight, University of WashingtonRC Millikan, University of North CarolinaTH Mosley, University of MississippiB Padhukasahasram, Henry Ford Health SystemLK Williams, Henry Ford Health SystemSR Patel, Brigham & Womens HospitalU Peters, Fred Hutchinson Cancer Research CenterCA Pettaway, University of Texas MD Anderson Cancer CenterPA Peyser, University of MichiganBM Psaty, University of WashingtonS Redline, Brigham & Womens HospitalCN Rotimi, NHGRIBA Rybicki, Henry Ford HospitalMM Sale, University of VirginiaPJ Schreiner, University of MinnesotaLB Signorello, Harvard UniversityAB Singleton, NIAJL Stanford, Fred Hutchinson Cancer Research CenterSS Strom, University of Texas MD Anderson Cancer CenterMichael Thun, Emory UniversityM Vitolins, Wake Forest UniversityW Zheng, Vanderbilt UniversityJH Moore, Dartmouth CollegeSM Williams, Dartmouth CollegeS Ketkar, NIAX Zhu, NCIAB Zonderman, NIAC Kooperberg, Fred Hutchinson Cancer Research CenterGJ Papanicolaou, NHLBIBE Henderson, University of Southern CaliforniaAP Reiner, Fred Hutchinson Cancer Research CenterJN Hirschhorn, Broad Institute of MIT and HarvardRJF Loos, Icahn School of Medicine at Mt SinaiKE North, University of North CarolinaCA Haiman, University of Southern California
Language
  • English
Date
  • 2013-06-01
Publisher
  • Nature Publishing Group
Publication Version
Copyright Statement
  • © 2013 Nature America, Inc. All rights reserved.
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 45
Issue
  • 6
Start Page
  • 690
End Page
  • +
Grant/Funding Information
  • None declared
Supplemental Material (URL)
Abstract
  • Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10 -8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10-7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. © 2013 Nature America, Inc. All rights reserved.
Author Notes
  • Correspondence: Christopher Haiman at Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Harlyne Norris Research Tower, 1450 Biggy Street, Room 1504, Los Angeles, CA 90033, USA. Tel: +1 3234427755, Fax: +1 3234427749, haiman@usc.edu
Keywords
Research Categories
  • Health Sciences, Oncology
  • Health Sciences, Epidemiology
  • Biology, Genetics
  • Health Sciences, Nutrition

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