Past, Present, and Future of Parkinson's Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy

• Type of Material: Article
• Authors: J.A. Obeso, Hospital Universitario HM Puerta del Sur; M. Stamelou, Philipps University; C.G. Goetz, Rush University; W. Poewe, Medical University of Innsbruck; A.E. Lang, Toronto Western Hospital; D. Weintraub, University of Pennsylvania; D. Burn, Newcastle University; G.M. Halliday, University of Sydney; E. Bezard, Université de Bordeaux; S. Przedborski, Columbia University; S. Lehericy, Sorbonne Universités; D.J. Brooks, Newcastle University; J.C. Rothwell, University College London; M. Hallett, National Institute of Neurological Disorders and Stroke; Mahlon R DeLong, Emory University; C. Marras, University of Toronto; C.M. Tanner, University of California; G.W. Ross, Veterans Affairs Pacific Islands Health Care System; J.W. Langston, Parkinson’s Institute; C. Klein, University of Lubeck; V. Bonifati, Erasmus University; J. Jankovic, Baylor College of Medicine; A.M. Lozano, University of Toronto; G. Deuschl, Christian Albrechts University; H. Bergman, Institute of Medical Research Israel-Canada; E. Tolosa, Hospital Clínic de Barcelona; M. Rodriguez-Violante, Movement Disorders Clinic; S. Fahn, Columbia University; R.B. Postuma, McGill University; D. Berg, University of Kiel
• Language: English
• Date: 2017-09-01
• Publisher: Wiley
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017 International Parkinson and Movement Disorder Society
• Final Published Version (URL): http://dx.doi.org/10.1002/mds.27115
• Title of Journal or Parent Work: Movement Disorders
• ISSN: 0885-3185
• Volume: 32
• Issue: 9
• Start Page: 1264
• End Page: 1310
• Keywords: IMPULSE CONTROL DISORDERS; POSITRON-EMISSION-TOMOGRAPHY; Neurosciences & Neurology; PATHOLOGICAL ALPHA-SYNUCLEIN; MILD COGNITIVE IMPAIRMENT; FOCUSED ULTRASOUND THALAMOTOMY; 200 years anniversary; MULTIPLE SYSTEM ATROPHY; Shaking Palsy; Clinical Neurology; PROGRESSIVE SUPRANUCLEAR PALSY; Parkinson's disease; SLEEP BEHAVIOR DISORDER; LEVODOPA-INDUCED DYSKINESIAS; Life Sciences & Biomedicine; Science & Technology; DEEP BRAIN-STIMULATION
• Research Categories: Health Sciences, Medicine and Surgery; Biology, Physiology; Biology, Neuroscience

Abstract

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.