Colistin Heteroresistance in Enterobacter cloacae Is Associated with Cross-Resistance to the Host Antimicrobial Lysozyme

• Type of Material: Article
• Authors: Brooke A. Napier, Emory University; Victor Band, Emory University; Eileen Burd, Emory University; David S Weiss, Emory University
• Language: English
• Date: 2014-09-01
• Publisher: American Society for Microbiology
• Publication Version: Final Published Version
• Copyright Statement: © 2014, American Society for Microbiology.
• Final Published Version (URL): http://dx.doi.org/10.1128/AAC.02432-14
• Title of Journal or Parent Work: Antimicrobial Agents and Chemotherapy
• ISSN: 0066-4804
• Volume: 58
• Issue: 9
• Start Page: 5594
• End Page: 5597
• Grant/Funding Information: D.S.W. was supported by a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease award.
• Keywords: PATHOGENS; ANTIBIOTIC-RESISTANCE; Science & Technology; Pharmacology & Pharmacy; Life Sciences & Biomedicine; COMPLEX; SUSCEPTIBILITY; ACINETOBACTER-BAUMANNII; STRAINS; PNEUMONIAE; Microbiology
• Research Categories: Health Sciences, Immunology; Health Sciences, Pathology

Abstract

Here, we describe the first identification of colistin-heteroresistant Enterobacter cloacae in the United States. Treatment of this isolate with colistin increased the frequency of the resistant subpopulation and induced cross-resistance to the host antimicrobial lysozyme. This is the first description ofheteroresistance conferring cross-resistance to a host antimicrobial and suggests that clinical treatment with colistin may inadvertently select for bacteria that are resistant to components of the host innate immune system. Copyright © 2014 American Society for Microbiology. All Rights Reserved.