Publication

CsrA and TnaB Coregulate Tryptophanase Activity To Promote Exotoxin-Induced Killing of Caenorhabditis elegansby Enteropathogenic Escherichia coli

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Last modified
  • 02/20/2025
Type of Material
Authors
    Shantanu Bhatt, Emory UniversityAkwasi Anyanful, Emory UniversityDaniel Kalman, Emory University
Language
  • English
Date
  • 2011-09
Publisher
  • American Society for Microbiology
Publication Version
Copyright Statement
  • © 2011, American Society for Microbiology. All Rights Reserved.
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 193
Issue
  • 17
Start Page
  • 4516
End Page
  • 4522
Grant/Funding Information
  • This work was supported by NIHgrants R01DK074731-01;and R01-A1056067-01to DK.
  • S.B. is the recipient of the National Science Foundation award no. 0450303, subaward no. I-66-606-63, to Emory University.
Abstract
  • Enteropathogenic Escherichia coli(EPEC) requires the tnaA-encoded enzyme tryptophanase and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.
Author Notes
  • Corresponding author. Mailing address: Department of Pathology, 615 Michael St., Atlanta, GA 30329. Phone: (404) 712-2326. Fax: (404) 712-2979. E-mail: dkalman@emory.edu.
Research Categories
  • Biology, Microbiology
  • Biology, Virology
  • Health Sciences, Immunology

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