2016 proceedings of the National Heart, Lung, and Blood Institute's scientific priorities in pediatric transfusion medicine

• Type of Material: Article
• Authors: Pablo Cure, National Heart, Lung, and Blood Institute; Melania Bembea, Johns Hopkins University Hospital; Stella Chou, Childrens Hospital of Philadelphia; Allan Doctor, St Louis Children's Hospital; Anne Eder, National Institutes of Health; Jeanne Hendrickson, Emory University; Cassandra Josephson, Emory University; Alan E Mast, Medical College of Wisconsin; William Savage, Brigham & Womens Hospital; Martha Sola-Visner, Children's Hospital Boston
• Language: English
• Date: 2017-06-01
• Publisher: Wiley
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2017 AABB
• Final Published Version (URL): http://dx.doi.org/10.1111/trf.14100
• Title of Journal or Parent Work: Transfusion
• Volume: 57
• Issue: 6
• Start Page: 1568
• End Page: 1581
• Grant/Funding Information: The meeting at the NIH/NHLBI was sponsored by NHLBI, the Food and Drug Administration, and the Department of Health and Human Services/Office of the Assistant Secretary of Health.
• Keywords: UNITED-STATES; MOUSE MODEL; RISK-FACTORS; WHOLE-BLOOD; Hematology; HEMOLYTIC-DISEASE; CRITICALLY-ILL CHILDREN; Science & Technology; ANTI-D; EXTRACORPOREAL MEMBRANE-OXYGENATION; SICKLE-CELL-DISEASE; PLATELET TRANSFUSIONS; Life Sciences & Biomedicine

Abstract

On April 5–6, 2016, the National Heart, Lung, and Blood Institute (NHLBI); the Department of Health and Human Services/Office of the Assistant Secretary of Health; and the Food and Drug Administration (FDA) sponsored a meeting on Scientific Priorities in Pediatric Transfusion Medicine at NHLBI in Bethesda, Maryland. The goal of this meeting was to identify important research questions that could be answered in the next 5 to 10 years and which would have the potential to transform the clinical practice of pediatric transfusion medicine. By applying basic, translational, and/or clinical research studies focused in six areas the science of/transfusion medicine would be advanced. The six areas were selected based on recognized gaps in knowledge and included neonatology and perinatology, oncology and transplant, chronic transfusion, devices and surgery, intensive care, and trauma and teenage blood donation. The meeting and premeeting teleconferences included 80 participants representing multiple stakeholders, academic medicine, the basic and clinical research community, and the government. The participants had expertise in multiple relevant disciplines including transfusion medicine, pediatrics, neonatology, hematology, surgery, critical care, trauma, internal medicine, epidemiology, and study design. The speakers and participants identified research priorities based on unmet needs in the pediatric transfusion medicine arena and proposed strategies to overcome the knowledge gaps and address unanswered questions.