Editorial: Exploring Novel Approaches to Eliminate HIV Reservoirs to Achieve a Cure for HIV

• Type of Material: Article
• Authors: Renée M van der Sluis, Aarhus University; Andrés Finzi Finzi, Université de Montréal; Matthew Parsons, Emory University
• Language: English
• Date: 2021-02-25
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Final Published Version
• Copyright Statement: © 2021 van der Sluis, Finzi and Parsons
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fcimb.2021.658848
• Title of Journal or Parent Work: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
• Volume: 11
• Start Page: 658848
• End Page: 658848
• Grant/Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 754513 and The Aarhus University Research Foundation (RMS).
• Keywords: Microbiology; Science & Technology; Immunology; STRATEGIES; human immunodeficiency virus (HIV); HIV cure; HIV latency; ANTIRETROVIRAL THERAPY; HIV cure research; HIV cure strategies; VIRAL LOAD; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Pathology; Health Sciences, Immunology; Health Sciences, Public Health

Abstract

Antiretroviral therapy (ART) has revolutionized the treatment of HIV and has dramatically reduced morbidity and mortality among people living with HIV (PLWH) (Antiretroviral Therapy Cohort Collaboration, 2017). ART inhibits HIV replication, decreasing viral loads, halting disease progression and preventing sexual transmission of the virus (Attia et al., 2009; Volberding and Deeks, 2010; Cohen et al., 2011; Bavinton et al., 2018; Rodger et al., 2019). Cessation of ART, however, allows HIV to re-initiate replication (Davey et al., 1999; Colby et al., 2018). As such, ART is required throughout the lifespan of PLWH. Treatments that aim to cure HIV or induce viral remission are highly desirable to alleviate the need for lifelong ART.