Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease

• Type of Material: Article
• Authors: Young-Man Kwon, Georgia State University; Hye Suk Hwang, Georgia State University; Jong-Seok Lee, Georgia State University; Eun-Ju Ko, Georgia State University; Si-Eun Yoo, Georgia State University; Min-Chul Kim, Animal and Plant Quarantine Agency; Ki-Hye Kim, Georgia State University; Yu-Hye Lee, Georgia State University; Jae-Min Song, Sungshin Women’s University; Sujin Lee, Emory University; Martin Moore, Emory University; Sang-Moo Kang, Georgia State University
• Language: English
• Date: 2014-04-01
• Publisher: Elsevier Masson
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2014 Elsevier B.V. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.antiviral.2014.01.008
• Title of Journal or Parent Work: Antiviral Research
• ISSN: 0166-3542
• Volume: 104
• Issue: 1
• Start Page: 1
• End Page: 6
• Grant/Funding Information: This work was supported by NIH/NIAID grants AI105170 (S.M.K.); AI093772 (S.M.K.); AI087782 (S.M.K.); 1R01AI087798 (MLM); and 1U19AI095227 (MLM).; The histology core facility in the Center for Inflammation, Immunity, & Infection was supported by Georgia Research Alliance.
• Keywords: Pharmacology & Pharmacy; RSV VACCINE; COTTON RATS; T-CELL RESPONSES; Maternal antibodies; Vaccine enhanced disease; EOSINOPHILIA; PULMONARY INFLAMMATORY RESPONSE; FI-RSV; INFECTION; Virology; G PROTEIN; MICE; Science & Technology; Passive immunization; PALIVIZUMAB; CHALLENGE; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Immunology; Biology, Virology

Abstract

Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.