Noncoding RNAs in the brain

• Type of Material: Article
• Authors: John S. Satterlee, National Institute on Drug Abuse; Scott Barbee, University of Denver; Peng Jin, Emory University; Anna Krichevsky, Brigham and Women's Hospital; Sofie Salama, University of California Santa Cruz; Gerhard Schratt, University of Heidelberg; Da-Yu Wu, National Institute on Drug Abuse
• Language: English
• Date: 2007-10-31
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Final Published Version
• Copyright Statement: Copyright © 2007 Society for Neuroscience.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1523/JNEUROSCI.3624-07.2007
• Title of Journal or Parent Work: Journal of Neuroscience Nursing
• ISSN: 0888-0395
• Volume: 27
• Issue: 44
• Start Page: 11856
• End Page: 11859
• Keywords: P-BODIES; X MENTAL-RETARDATION; development; NUCLEAR; Neurosciences; human forebrain development; Purkinje neurons; CREB; Life Sciences & Biomedicine; PATHWAY; differentiation; MECHANISMS; Science & Technology; epigenetic; synaptic plasticity; neurogenesis; RNA; learning and memory; MICRORNAS; PROTEIN; Neurosciences & Neurology; brain development; CENTRAL-NERVOUS-SYSTEM; MIR-124; dendritic spine; MEMORY
• Research Categories: Biology, Neuroscience; Biology, Genetics

Abstract

Cells transcribe thousands of RNAs that do not appear to encode proteins. The neuronal functions of these noncoding RNAs (ncRNAs) are for the most part not known, but specific ncRNAs have been shown to regulate dendritic spine development, neuronal fate specification and differentiation, and synaptic protein synthesis. ncRNAs have been implicated in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome. Future studies will likely identify additional neuronal functions for ncRNAs as well as roles for these molecules in other neuropsychiatric and neurodevelopmental disorders.