Publication

Inflammasome/IL-1 beta responses to streptococcal pathogens

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Last modified
  • 05/15/2025
Type of Material
Authors
    Christopher LaRock, Emory UniversityVictor Nizet, University of California San Diego
Language
  • English
Date
  • 2015-10-08
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2015 LaRock and Nizet.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 6
Issue
  • OCT
Start Page
  • 518
End Page
  • 518
Grant/Funding Information
  • Streptococcal research in the Nizet lab is supported by NIH grants AI077780 and AI096837. CL received fellowship support from the A.P. Giannini foundation.
Abstract
  • Inflammation mediated by the inflammasome and the cytokine IL-1β are some of the earliest and most important alarms to infection. These pathways are responsive to the virulence factors that pathogens use to subvert immune processes, and thus are typically activated only by microbes with potential to cause severe disease. Among the most serious human infections are those caused by the pathogenic streptococci, in part because these species numerous strategies for immune evasion. Since the virulence factor armament of each pathogen is unique, the role of IL-1β and the pathways leading to its activation varies for each infection. This review summarizes the role of IL-1β during infections caused by streptococcal pathogens, with emphasis on emergent mechanisms and concepts countering paradigms determined for other organisms.
Author Notes
Keywords
Research Categories
  • Chemistry, Pharmaceutical
  • Health Sciences, General

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