A Severe Episode of Hemolytic Anemia After Amoxicillin Exposure in A G6PD Deficient Patient.

• Type of Material: Article
• Authors: Carmelo Blanquicett, Emory University; Tapasya Raavi, Emory University; Stephanie M. Robert, Yale University
• Language: English
• Date: 2019
• Publisher: Fortune Journals
• Publication Version: Final Published Version
• Copyright Statement: © 2019, Copyrights Fortune Journals. All Rights Reserved!
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.26502/acmcr.96550068
• Title of Journal or Parent Work: Archives of Clinical and Medical Case Reports
• Volume: 3
• Issue: 3
• Start Page: 104
• End Page: 112
• Grant/Funding Information: This material is the result of work supported in part with resources and the use of facilities at the Atlanta VA Medical Center and the Moffitt Cancer Center.
• Keywords: Glucose-6-phosphate dehydrogenase; Hemolytic anemia; Enzyme deficiency; Amoxicillin

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide, with genetic variants resulting in a range of phenotypes that vary from asymptomatic to severe hemolysis. We report a case of severe hemolytic anemia in a G6PD deficient patient whose only known exposure was amoxicillin two weeks prior to his episode of severe hemolysis, for which he presented to our hospital. An extensive infectious and hematologic workup resulted negative with the exception of a positive G6PD deficiency result. Although rare, we suggest that the patient's severe hemolytic anemia is possibly related to amoxicillin exposure.