Unrecognized glucose intolerance is not associated with depression. Screening for Impaired Glucose Tolerance study 3 (SIGT 3)

• Type of Material: Article
• Authors: D. Musselman, Emory University; Viola Vaccarino, Emory Program in Cardiovascular Outcomes Research and Epidemiology; P. Kolm, Christiana Care Center for Outcomes Research; W. S. Weintraub, Christiana Care Center for Outcomes Research; Jane M. Caudle, Emory University; R. M. Varughese, Emory University; Jade M. Irving, Emory University; Mary Rhee, Emory University; David Carleton Ziemer, Emory University; Lawrence S Phillips, Emory University
• Language: English
• Date: 2008-11
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2008 The Authors. Journal compilation © 2008 Diabetes UK
• Final Published Version (URL): http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2008.02543.x/abstract
• Title of Journal or Parent Work: Diabetic Medicine
• ISSN: 0742-3071
• Volume: 25
• Issue: 11
• Start Page: 1361
• End Page: 1365
• Grant/Funding Information: This work was supported in part by DK070715 and RR017643 (MKR), the Dana Foundation and Forest Pharmaceuticals (DM), HS07922 and DK066204 (LSP, WSW, PK and VV), K24HL077506, K24HL077506, R01HL68630 and R01AG026255 (VV) and RR00039.
• Keywords: diabetes; impaired glucose tolerance; psychosocial
• Research Categories: Health Sciences, Mental Health; Psychology, General; Biology, Physiology

Abstract

Aims: To understand the metabolic and temporal links in the relationship between diabetes and depression, we determined the association between depressive symptoms and unrecognized glucose intolerance. Methods: In a cross-sectional study, 1047 subjects without known diabetes were screened for diabetes or pre-diabetes using the oral glucose tolerance test and for depressive symptoms using the Patient Health Questionnaire (PHQ). Results: Mean age was 48 years, body mass index 30 kg/m2; 63% were female, 54% black, 11% previously treated for depression and 10% currently treated; 5% had diabetes and 34% pre-diabetes. Median PHQ score was 2 (interquartile range 0–5). Depressive symptoms did not increase with worsening glucose tolerance, after adjusting for age, sex, ethnicity, body mass index, family history, exercise, education and depression treatment. Conclusions: There is no association between depressive symptoms and unrecognized glucose intolerance. However, it remains possible that diagnosed diabetes, with its attendant health concerns, management issues, and/or biological changes, may be a risk for subsequent development of depression. Thus, patients with newly diagnosed diabetes should be counselled appropriately and monitored for the development of depression.