Effects of Sunlight and Diet on Vitamin D Status of Pulmonary Tuberculosis Patients in Tbilisi, Georgia

• Type of Material: Article
• Authors: Nirali S. Desai, Emory University; Nestani Tukvadze, National Center for Tuberculosis and Lung Diseases (NCTBLD), Georgia; Jennifer Frediani, Emory University; Maia Kipiani, National Center for Tuberculosis and Lung Diseases (NCTBLD); Eka Sanikidze, National Center for Tuberculosis and Lung Diseases (NCTBLD); Memorie M. Nichols, Emory University; Gautam Hebbar, Emory University; Russell Ryan Kempker, Emory University; Veriko Mirtskhulava, National Center for Tuberculosis and Lung Diseases (NCTBLD); Iagor Kalandadze, National Center for Tuberculosis and Lung Diseases (NCTBLD); Nilay Sutaria, Boston University; Tai C. Chen, Boston University; Henry Michael Blumberg, Emory University; Thomas R Ziegler, Emory University; Vin Tangpricha, Emory University; Shabnam Seydafkan, Emory University
• Language: English
• Date: 2012-04
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012, Elsevier
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.nut.2011.08.012
• Title of Journal or Parent Work: Nutrition
• ISSN: 0899-9007
• Volume: 28
• Issue: 4
• Start Page: 362
• End Page: 366
• Grant/Funding Information: Supported in part by a grants from the Emory University Global Health Institute (TRZ, VT, HMB), National Institutes of Health grants # K23 K23AR054334 (VT), #K24 RR023356 (TRZ), #1U1RR025771 (TRZ), #1U1RR025771 (HMB, TRZ, VT), #UL RR025008 (HMB, TRZ, VT), D43TW007124 (HMB), and D43TW007124-06S109 (RRK)
• Keywords: cholecalciferol; 7-dehydrocholesterol; dietary intake
• Research Categories: Health Sciences, Nutrition; Health Sciences, Medicine and Surgery

Abstract

Vitamin D deficiency is common in tuberculosis (TB) and this may modulate immune responses.Objective To determine vitamin D status in patients with TB and examine sources of vitamin D in Tbilisi, Georgia. Research Methods and Procedures We measured plasma 25-hydroxyvitamin D (25(OH)D) and dietary vitamin D intake in pulmonary TB patients (n=85) in Tbilisi, Georgia. To determine the impact of season on vitamin D status, we tested in vitro conversion of 7-dehydrocholesterol (7-DHC) to previtamin D3 after sunlight exposure. Results In TB subjects, mean plasma 25(OH)D concentrations were 14.5 ± 7.0 ng/mL, and vitamin D insufficiency (25(OH)D < 30 ng/mL) occurred in 97% of subjects. Dietary sources of vitamin D were mainly fish, eggs, and butter. Daily intake was well below recommended daily intakes in TB subjects (172 IU + 196 IU). The conversion of 7-DHC to previtamin D3 was undetectable between October to March, and highest in June and July between 11:00 and 14:00 h. Conclusion Insufficient vitamin D dietary intake and limited production of vitamin D from sunlight during the majority of the year, may explain the high prevalence of vitamin D insufficiency TB patients in Tbilisi.