Prenatal Exposure to Mixtures of Persistent Endocrine-disrupting Chemicals and Birth Size in a Population-based Cohort of British Girls

• Type of Material: Article
• Authors: Kristin J Marks, Emory University; Penelope Howards, Emory University; Melissa Smarr, Emory University; William Flanders, Emory University; Kate Northstone, Bristol Medical School, Oakfield House; Johnni H Daniel, National Center for Environmental Health; Andreas Sjodin, National Center for Environmental Health; Antonia M Calafat, National Center for Environmental Health; Terryl Hartman, Emory University
• Language: English
• Date: 2021-07-01
• Publisher: LIPPINCOTT WILLIAMS & WILKINS
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 Wolters Kluwer Health, Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1097/EDE.0000000000001351
• Title of Journal or Parent Work: EPIDEMIOLOGY
• Volume: 32
• Issue: 4
• Start Page: 573
• End Page: 582
• Grant/Funding Information: The UK Medical Research Council and the Wellcome Trust (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grant funding is available on the ALSPAC website. This work was specifically funded by the Centers for Disease Control and Prevention (AY5350).
• Keywords: GROWTH; AGE; PERFLUORINATED COMPOUNDS; Pregnancy; Science & Technology; Birth weight; PERFLUOROALKYL SUBSTANCES; ALSPAC; Life Sciences & Biomedicine; PREGNANCY; Polychlorinated biphenyls; Organochlorine pesticides; POLYCHLORINATED-BIPHENYLS PCBS; Perfluoroalkyl and polyfluoroalkyl substances; Endocrine disruptors; CORD BLOOD; WEIGHT; Public, Environmental & Occupational Health; HEALTH; POLYBROMINATED BIPHENYLS

Abstract

Background: Previous studies of endocrine-disrupting chemicals have examined one of these chemicals at a time in association with an outcome; studying mixtures better approximates human experience. We investigated the association of prenatal exposure to mixtures of persistent endocrine disruptors (perfluoroalkyl and polyfluoroalkyl substances [PFAS], polychlorinated biphenyls [PCBs], and organochlorine pesticides) with birth size among female offspring in the Avon Longitudinal Study of Parents and Children (ALSPAC), based in the United Kingdom in 1991-1992. Methods: We quantified concentrations of 52 endocrine-disrupting chemicals in maternal serum collected during pregnancy at median 15-week gestation. Birth weight, crown-to-heel length, and head circumference were measured at birth; ponderal index and small for gestational age were calculated from these. We used repeated holdout Weighted Quantile Sum (WQS) regression and Bayesian kernel machine regression to examine mixtures in 313 mothers. Results: Using WQS regression, all mixtures (each chemical class separately and all three together) were inversely associated with birth weight. A one-unit increase in WQS index (a one-decile increase in chemical concentrations) for all three classes combined was associated with 55 g (β = -55 g, 95% confidence interval [CI] = -89, -22 g) lower birth weight. Associations were weaker but still inverse using Bayesian kernel machine regression. Under both methods, PFAS were the most important contributors to the association with birth weight. We also observed inverse associations for crown-to-heel length. Conclusions: These results are consistent with the hypothesis that prenatal exposure to mixtures of persistent endocrine-disrupting chemicals affects birth size.