Cilia bent out of shape over dysfunctional astrocyte mitochondria

• Type of Material: Article
• Authors: Rachel M Bear, Emory University; Tamara Caspary, Emory University
• Language: English
• Date: 2022-12-16
• Publisher: ROCKEFELLER UNIV PRESS
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Bear and Caspary
• License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1083/jcb.202211123
• Title of Journal or Parent Work: JOURNAL OF CELL BIOLOGY
• Volume: 222
• Issue: 1
• Grant/Funding Information: This work was funded by National Institutes of Health grant R35 GM122549 to T. Caspary and grant F31 NS125984 to R.M. Bear.
• Keywords: Science & Technology; Life Sciences & Biomedicine; Cell Biology
• Research Categories: Biology, Neuroscience

Abstract

Mitochondrial dysfunction in astrocytes drives neurodegenerative brain pathology. In this issue, Ignatenko et al. (2022. J. Cell. Biol. https://doi.org/10.1083/jcb.202203019) discover a novel connection between cilia and mitochondria in astrocytes, whereby mitochondrial dysfunction leads to abnormal cilia structure and a motile cilia program.