Use of mouse models to study the mechanisms and consequences of RBC clearance

• Type of Material: Article
• Authors: E. A. Hod, Columbia University; S.A. Arinsburg, Columbia University; R.O. Francis, Columbia University; James Zimring, Emory University; Jeanne Hendrickson, Emory University; S. L. Spitalnik, Columbia University
• Language: English
• Date: 2010-08-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 International Society of Blood Transfusion.
• Final Published Version (URL): http://dx.doi.org/10.1111/j.1423-0410.2010.01327.x
• Title of Journal or Parent Work: Vox Sanguinis
• ISSN: 0042-9007
• Volume: 99
• Issue: 2
• Start Page: 99
• End Page: 111
• Keywords: AUTOIMMUNE HEMOLYTIC-ANEMIA; Life Sciences & Biomedicine; IN-VIVO; TRANSGENIC MICE; Transfusion reactions; REGULATORY T-CELLS; BETA-GLOBIN GENE; Science & Technology; FC-GAMMA; COMPLEMENT-FIXING SITES; RBC antigens and antibodies; PRIMARY ANTIBODY-RESPONSES; RED-BLOOD-CELLS; Immuno-haematology; Hematology; RECEPTOR-MEDIATED PHAGOCYTOSIS
• Research Categories: Health Sciences, Pathology; Biology, Cell

Abstract

Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.