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Longitudinal Profiles of Neighborhood Socioeconomic Vulnerability Influence Blood Pressure Changes Across the Female Midlife Period

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  • 07/07/2026
Type of Material
Authors
    Mary D. Schiff, University of PittsburghChristina F. mair, University of PittsburghEmma Barinas-Mitchell, University of PittsburghMaria M. Brooks, University of PittsburghDara D. Méndez, University of PittsburghAshley I. Naimi, Emory UniversityAlexis Reeves, Stanford UniversityMonique Hedderson, Kaiser Permanente Northern CaliforniaImke Janssen, Rush UniversityAnthony Fabio, University of Pennsylvania
Language
  • English
Date
  • 2023-05-02
Publisher
  • Elsevier
Publication Version
Copyright Statement
  • © 2023 Elsevier Ltd. All rights reserved.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 82
Start Page
  • 103033
Grant/Funding Agency
  • National Institutes of Health
Grant/Funding Information
  • The Study of Women’s Health Across the Nation (SWAN) has grant support from the National Institutes of Health (NIH), DHHS, through the National Institute on Aging (NIA), the National Institute of Nursing Research (NINR) and the NIH Office of Research on Women’s Health (ORWH) (Grants U01NR004061; U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495, and U19AG063720).
Supplemental Material (URL)
Abstract
  • Purpose: To examine whether longitudinal exposure to neighborhood socioeconomic vulnerability influences blood pressure changes throughout midlife in a racially, ethnically, and geographically-diverse cohort of women transitioning through menopause. Methods: We used longitudinal data on 2,738 women (age 42–52 at baseline) living in six United States cities from The Study of Women’s Health Across the Nation. Residential histories, systolic blood pressures (SBP), and diastolic blood pressures (DBP) were collected annually for ten years. We used longitudinal latent profile analysis to identify patterns of neighborhood socioeconomic vulnerability occurring from 1996–2007 in participant neighborhoods. We used linear mixed-effect models to determine if a woman’s neighborhood profile throughout midlife was associated with blood pressure changes. Results: We identified four unique profiles of neighborhood socioeconomic vulnerability – differentiated by residential socioeconomic status, population density, and vacant housing conditions – which remained stable across time. Women residing in the most socioeconomically vulnerable neighborhoods experienced the steepest increase in annual SBP growth by 0.93 mmHg/year (95% CI: 0.65–1.21) across ten-year follow-up. Conclusions: Neighborhood socioeconomic vulnerability was significantly associated with accelerated SBP increases throughout midlife among women.
Author Notes
  • Competing interests: None.
  • Correspondence: Anthony Fabio; Epidemiology Data Center, 4420 Bayard Street, Suite 600, Pittsburgh, PA, 15260; Phone: 412-624-4612, afabio@pitt.edu
  • Acknowledgements: Clinical Centers: University of Michigan, Ann Arbor - Carrie Karvonen-Gutierrez, PI 2021 - present, Siobán Harlow, PI 2011 - 2021, MaryFran Sowers, PI 1994-2011; Massachusetts General Hospital, Boston, MA - Sherri-Ann Burnett-Bowie, PI 2020 - Present; Joel Finkelstein, PI 1999 - 2020; Robert Neer, PI 1994 - 1999; Rush University, Rush University Medical Center, Chicago, IL - Imke Janssen, PI 2020 - Present; Howard Kravitz, PI 2009 - 2020; Lynda Powell, PI 1994 - 2009; University of California, Davis/Kaiser - Elaine Waetjen and Monique Hedderson, PIs 2020 - Present; Ellen Gold, PI 1994 - 2020; University of California, Los Angeles - Arun Karlamangla, PI 2020 - Present; Gail Greendale, PI 1994 - 2020; Albert Einstein College of Medicine, Bronx, NY - Carol Derby, PI 2011 - present, Rachel Wildman, PI 2010 - 2011; Nanette Santoro, PI 2004 - 2010; University of Medicine and Dentistry - New Jersey Medical School, Newark - Gerson Weiss, PI 1994 - 2004; and the University of Pittsburgh, Pittsburgh, PA - Rebecca Thurston, PI 2020 - Present; Karen Matthews, PI 1994 - 2020. NIH Program Office: National Institute on Aging, Bethesda, MD - Rosaly Correa-de-Araujo 2020 - present; Chhanda Dutta 2016- present; Winifred Rossi 2012-2016; Sherry Sherman 1994 - 2012; Marcia Ory 1994 - 2001; National Institute of Nursing Research, Bethesda, MD - Program Officers. Central Laboratory: University of Michigan, Ann Arbor - Daniel McConnell (Central Ligand Assay Satellite Services). Coordinating Center: University of Pittsburgh, Pittsburgh, PA - Maria Mori Brooks, PI 2012 - present; Kim Sutton-Tyrrell, PI 2001 - 2012; New England Research Institutes, Watertown, MA - Sonja McKinlay, PI 1995 - 2001. Steering Committee: Susan Johnson, Current Chair Chris Gallagher, Former Chair We thank the study staff at each site and all the women who participated in SWAN.
Keywords
Subject - Topics
  • Social conditions
  • Economic conditions
  • Women--Health and hygiene

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