Precision prevention of type 2 diabetes: An approach to revitalize current lifestyle interventions

• Type of Material: Article
• Authors: Sathish Thirunavukkarasu, Emory University
• Language: English
• Date: 2023-06-02
• Publisher: ELSEVIER IRELAND LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2023 Elsevier B.V. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.diabres.2023.110722
• Title of Journal or Parent Work: DIABETES RESEARCH AND CLINICAL PRACTICE
• Volume: 200
• Start Page: 110722
• End Page: 110722
• Keywords: Prediabetes; Science & Technology; Life Sciences & Biomedicine; Diabetes; Precision prevention; Endocrinology & Metabolism; Lifestyle change
• Research Categories: Health Sciences, Nutrition; Health Sciences, Public Health

Abstract

I read with great interest the review article by Golovaty et al.[1] calling to innovate and revitalize current approaches to lifestyle change for preventing type 2 diabetes. For this purpose, they identified six key priority areas, one of which was detecting high-risk individuals, such as those with prediabetes, who are most likely to benefit from intensive lifestyle interventions. I would like to point out that prediabetes is not a singular entity but a heterogenous group characterized by different phenotypes based on the pathophysiology [2, 3], risk of progression to type 2 diabetes [4] and clusters of risk factors [5]. Consequently, the “one-size-fits-all” lifestyle modification approach may not apply to different prediabetes phenotypes.