Publication

Genetically Determined Height and Risk of Non-hodgkin Lymphoma

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Last modified
  • 05/21/2025
Type of Material
Authors
    Amy Moore, National Cancer InstituteEleanor Kane, University of YorkZhaoming Wang, St Jude Childrens Research HospitalOrestis A Panagiotou, Brown UniversityLauren R Teras, American Cancer SocietyAlain Monnereau, INSERMNicole Wong Doo, Cancer Council VictoriaMitchell J Machiela, National Cancer InstituteChristine Skibola, Emory UniversitySusan Gapstur, Emory University
Language
  • English
Date
  • 2020-01-28
Publisher
  • Frontiers Media SA
Publication Version
Copyright Statement
  • © Copyright © 2020 Moore, Kane, Wang, Panagiotou, Teras, Monnereau, Wong Doo, Machiela, Skibola, Slager, Salles, Camp, Bracci, Nieters, Vermeulen, Vijai, Smedby, Zhang, Vajdic, Cozen, Spinelli, Hjalgrim, Giles, Link, Clavel, Arslan, Purdue, Tinker, Albanes, Ferri, Habermann, Adami, Becker, Benavente, Bisanzi, Boffetta, Brennan, Brooks-Wilson, Canzian, Conde, Cox, Curtin, Foretova, Gapstur, Ghesquières, Glenn, Glimelius, Jackson, Lan, Liebow, Maynadie, McKay, Melbye, Miligi, Milne, Molina, Morton, North, Offit, Padoan, Patel, Piro, Ravichandran, Riboli, de Sanjose, Severson, Southey, Staines, Stewart, Travis, Weiderpass, Weinstein, Zheng, Chanock, Chatterjee, Rothman, Birmann, Cerhan and Berndt.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 9
Start Page
  • 1539
End Page
  • 1539
Grant/Funding Information
  • This work was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute.
  • Support for individual studies can be found in the original publication.
Supplemental Material (URL)
Abstract
  • Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
Author Notes
  • See publication for full list of authors.
Keywords
Research Categories
  • Health Sciences, Oncology
  • Biology, Genetics

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