Delay in achieving enteral autonomy and growth outcomes in very low birth weight infants with surgical necrotizing enterocolitis

• Type of Material: Article
• Authors: Kera McNelis, Cincinnati Children’s Hospital Medical Center; Gillian Goddard, Cincinnati Children’s Hospital Medical Center; Todd Jenkins, Cincinnati Children’s Hospital Medical Center; Anne Poindexter, University of Cincinnati; Jacqueline Wessel, Cincinnati Children’s Hospital Medical Center; Michael Helmrath, University of Cincinnati; Brenda Poindexter, Emory University
• Language: English
• Date: 2020-12-02
• Publisher: SPRINGERNATURE
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s), under exclusive licence to Springer Nature America, Inc. 2020.
• Final Published Version (URL): http://dx.doi.org/10.1038/s41372-020-00880-z
• Title of Journal or Parent Work: JOURNAL OF PERINATOLOGY
• Volume: 41
• Issue: 1
• Start Page: 150
• End Page: 156
• Grant/Funding Information: This project was supported in part by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number 5UL1TR001425-03. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
• Keywords: Life Sciences & Biomedicine; Pediatrics; Obstetrics & Gynecology; INTESTINAL FAILURE; PRETERM INFANTS; NUTRITION; Science & Technology; SHORT-BOWEL SYNDROME
• Research Categories: Health Sciences, Medicine and Surgery; Biology, General

Abstract

Objective: To understand the nutritional intake and growth outcomes of very low birth weight infants with surgical necrotizing enterocolitis (NEC). Study design: In a retrospective cohort study, linear mixed models were used to compare growth outcomes from birth to 24 months corrected age for very low birth weight (VLBW) infants with surgical NEC to those with spontaneous intestinal perforation (SIP). Kaplan-Meier curves were developed to demonstrate the duration of parenteral nutrition (PN) use. Result: Height differed by surgical NEC and SIP over time (interaction p = 0.03). Surviving infants with surgical NEC had lower head circumference z-scores at 24 months. Of infants surviving surgical NEC, 71% received PN for >60 days after diagnosis. Conclusion: The majority of infants with surgical NEC have a delay in achieving enteral autonomy. There was a difference in linear catch-up growth over time between infants with SIP and surgical NEC at 24 months.