Dynamic T cell migration program provides resident memory within intestinal epithelium

• Type of Material: Article
• Authors: David Masopust, Emory University; Daniel Choo, Emory University; Vaiva Vezys, Emory University; E. John Wherry, Emory University; Jaikumar Duraiswamy, Emory University; Rama Akondy, Emory University; Jun Wang, Emory University; Kerry A. Casey, University of Minnesota; Daniel L. Barber, Emory University; Kim S. Kawamura, Emory University; Kathryn A. Fraser, University of Minnesota; Richard J. Webby, St. Jude Children’s Research Hospital, Memphis; Volker Brinkmann, Novartis Institutes for Biomedical Research; Eugene C. Butcher, Stanford University; Kenneth Newell, Emory University; Rafi Ahmed, Emory University
• Language: English
• Date: 2010-03-15
• Publisher: Rockefeller University Press
• Publication Version: Final Published Version
• Copyright Statement: © 2010 Masopust et al.
• License: Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
• Final Published Version (URL): http://jem.rupress.org/content/207/3/553
• Title of Journal or Parent Work: Journal of Experimental Medicine
• ISSN: 0022-1007
• Volume: 207
• Issue: 3
• Start Page: 553
• End Page: 564
• Grant/Funding Information: This work was supported by grants from the National Institutes of Health and the Arnold and Mabel Beckman Foundation.
• Research Categories: Health Sciences, Immunology

Abstract

Migration to intestinal mucosa putatively depends on local activation because gastrointestinal lymphoid tissue induces expression of intestinal homing molecules, whereas skin-draining lymph nodes do not. This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. We further demonstrate that memory T cells within small intestine epithelium do not routinely recirculate with memory T cells in other tissues, and we provide evidence that homing is similarly dynamic in humans after subcutaneous live yellow fever vaccine immunization. These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation.