Temporal Trends of Phenol, Paraben, and Triclocarban Exposure in California Pregnant Women during 2007-2014

• Type of Material: Article
• Authors: Kyunghoon Kim, University of Texas Arlington; Hyeong-Moo Shin, University of Texas Arlington; Stefanie A Busgang, Icahn School of Medicine at Mount Sinai; Dana Barr, Emory University; Parinya Panuwet, Emory University; Rebecca J Schmidt, University of California Davis; Irva Hertz-Picciotto, University of California Davis; Deborah H Bennett, University of California Davis
• Language: English
• Date: 2021-08-04
• Publisher: AMER CHEMICAL SOC
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 American Chemical Society
• Final Published Version (URL): http://dx.doi.org/10.1021/acs.est.1c01564
• Title of Journal or Parent Work: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• Volume: 55
• Issue: 16
• Start Page: 11155
• End Page: 11165
• Grant/Funding Information: This research was supported by grants from the National Institutes of Health (R21-ES025551, R21-ES028131, R01-ES020392, R24-ES028533, P30-ES023513, P01-ES011269, U2C-ES026555, U2C-ES026560, P30-ES019776, U54-HD079125, UH3-OD023342), the U.S. Environmental Protection Agency (83543201), and the UC Davis MIND Institute.
• Keywords: social forces; personal care products; PREDICTORS; FETAL EXPOSURE; temporal changes; Environmental Sciences; BISPHENOL-A CONCENTRATIONS; bisphenols; NUTRITION EXAMINATION SURVEY; Engineering; Life Sciences & Biomedicine; ENVIRONMENTAL PHENOLS; Science & Technology; URINARY CONCENTRATIONS; Environmental Sciences & Ecology; REPRODUCTIVE HEALTH; NATIONAL-HEALTH; regulations; VARIABILITY; Technology; PRENATAL EXPOSURE; geographic variations; Engineering, Environmental

Abstract

Little is known about temporal trends of pregnant women's exposures to environmental phenols and parabens. We quantified four phenols [bisphenol A (BPA), bisphenol F, bisphenol S, and triclosan), four parabens [butyl paraben, ethyl paraben (ETPB), methyl paraben (MEPB), and propyl paraben (PRPB)], and triclocarban in 760 urine samples collected during 2007-2014 from 218 California pregnant women participating in a high-familial risk autism spectrum disorder cohort. We applied multiple regression to compute least square geometric means of urinary concentrations and computed average annual percent changes. We compared our urinary concentrations with those of other study populations to examine geographic variations in pregnant women's exposure to these target compounds. Urinary concentrations of BPA, MEPB, ETPB, and PRPB in this study population decreased over the study period [percent change per year (95% confidence interval): -5.7% (-8.2%, -3.2%); -13.0% (-18.1%, -7.7%); -5.5% (-11.0%, 0.3%); and -13.3% (-18.3%, -8.1%), respectively] and were consistently lower than those in pregnant women in other U.S. regions during the same study period. In recent years, certain phenols and parabens with known adverse health effects are being regulated or replaced with alternatives, which explains decreased body burdens observed in this study population. Either the national regulations or the advocacy campaigns in California may have influenced exposures or consumer product choices.