Preterm infant with diprosopus and holoprosencephaly

• Type of Material: Article
• Authors: Nitya M Nair, Emory University; Daniel T Swarr, Cincinnati Children's Hospital Medical Center; Maria E Barnes-Davis, Cincinnati Children's Hospital Medical Center
• Language: English
• Date: 2021-12-01
• Publisher: John Wiley & Sons, Inc.
• Publication Version: Final Published Version
• Copyright Statement: © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/ccr3.5163
• Title of Journal or Parent Work: Clinical Case Reports
• Volume: 9
• Issue: 12
• Keywords: holoprosencephaly; diprosopus
• Research Categories: Health Sciences, Human Development

Abstract

Diprosopus is an extremely rare congenital anomaly involving craniofacial duplication. The etiology and pathophysiology remain unknown, and no genetic mutations have been definitively associated with the condition. This case describes an infant born at 27-weeks completed gestation with multiple congenital anomalies including diprosopus and discusses the implications of prenatal diagnosis.