Publication

Immune Microenvironment in Glioblastoma Subtypes

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Last modified
  • 05/15/2025
Type of Material
Authors
    Zhihong Chen, Emory UniversityDolores Hambardzumyan, Emory University
Language
  • English
Date
  • 2018-05-08
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2018 Chen and Hambardzumyan.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 9
Issue
  • MAY
Start Page
  • 1004
End Page
  • 1004
Grant/Funding Information
  • This work is supported by NIH grants U01-CA160882 and R01-NS100864 to DH.
Abstract
  • Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to their malignant growth and invasion into the brain parenchyma coupled with resistance to therapy, GBMs are among the deadliest of all cancers. GBMs are highly heterogeneous at both the molecular and histological levels. Hallmark histological structures include pseudopalisading necrosis and microvascular proliferation. In addition to high levels of intratumoral heterogeneity, GBMs also exhibit high levels of inter-tumoral heterogeneity. The major non-neoplastic cell population in the GBM microenvironment includes cells of the innate immune system called tumor-associated macrophages (TAMs). Correlative data from the literature suggest that molecularly distinct GBM subtypes exhibit differences in their microenvironment. Data from mouse models of GBM suggest that genetic driver mutations can create unique microenvironments. Here, we review the origin, features, and functions of TAMs in distinct GBM subtypes. We also discuss their interactions with other immune cell constituents and discuss prospects of therapeutically targeting TAMs to increase the efficacy of T-cell functions.
Author Notes
Keywords
Research Categories
  • Health Sciences, Immunology
  • Health Sciences, General

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