Associations among depression, suicidal behavior, and quality of life in patients with human immunodeficiency virus

• Type of Material: Article
• Authors: Gianluca Serafini, University of Genoa; Franco Montebovi, Sant’Andrea Hospital; Dorian Lamis, Emory University; Denise Erbuto, Sant’Andrea Hospital; Paolo Girardi, Sant’Andrea Hospital; Mario Amore, University of Genoa; Maurizio Pompili, Sant’Andrea Hospital
• Language: English
• Date: 2015-08-12
• Publisher: Baishideng Publishing
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2015.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.5501/wjv.v4.i3.303
• Title of Journal or Parent Work: World Journal of Virology
• ISSN: 2220-3249
• Volume: 4
• Issue: 3
• Start Page: 303
• End Page: 312
• Keywords: Human immunodeficiency virus infection; Major depression; Quality of life; Suicidal behavior
• Research Categories: Health Sciences, Mental Health; Biology, Virology; Health Sciences, Immunology

Abstract

Aim: To investigate the potential associations among major depression, quality of life, and suicidal behavior in human immunodeficiency virus (HIV) patients. Methods: A detailed MEDLINE search was carried out to identify all articles and book chapters in English published from January 1995 to January 2015. Results: Based on the main findings, the prevalence of major depressive disorder (MDD) ranged from 14.0% to 27.2%. Furthermore, the prevalence of suicidal ideation varied from 13.6% to 31.0% whereas, attempted suicides were reported to range from 3.9% to 32.7%. Interestingly, various associated risk factors for both depression and suicide were identified in HIV patients. Finally, consistent associations were reported among MDD, suicidal ideation, and poor quality of life in individuals living with HIV. Conclusion: Although additional studies are needed to elucidate this complex association, our results suggest the importance of early detection of both MDD and suicidality in patients living with HIV.