Association Between Symptoms of Chronic Psychological Distress and Myocardial Ischemia Induced by Mental Stress in Patients With Coronary Artery Disease

• Type of Material: Article
• Authors: Kasra Moazzami, Emory University; Mariana Garcia, Emory University; Samaah Sullivan, University of Texas, Houston; Tene T. Lewis, Emory University; J. Douglas Bremner, Emory University; Alexander C. Razavi, Emory University; Lucy H Shallenberger, Emory University; Yan Sun, Emory University; Paolo Raggi, University of Alberta; Amit Shah, Emory University; Arshed Ali Quyyumi, Emory University; Viola Vaccarino, Emory University
• Language: English
• Date: 2023-11-06
• Publisher: Wiley
• Publication Version: Final Published Version
• Copyright Statement: © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): https://doi.org/10.1161/JAHA.123.030305
• Title of Journal or Parent Work: Journal of the American Heart Association
• Volume: 12
• Issue: 21
• Start Page: e030305
• Grant/Funding Information: This work was supported by grants P01 HL101398, R01 HL109413, R01HL109413‐02S1, R01HL125246, K24HL077506, K24 MH076955, UL1TR000454, KL2TR000455, K23HL127251, K12HD085850, K01HL149982, L30HL148912, and T32HL130025 from the National Institutes of Health.
• Keywords: cardiology; mental stress–induced myocardial ischemia; psychological distress; coronary artery disease; myocardial infraction
• Research Categories: Psychology, Behavioral; Health Sciences, Mental Health

Abstract

Background Mental stress–induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease and is associated with a greater risk of future cardiovascular events. The association between chronic symptoms of psychological distress and mental stress–induced ischemia is not clear. Methods and Results We used a composite score of psychological distress derived from symptoms of depression, posttraumatic stress disorder, anxiety, anger, and perceived general stress. Participants underwent myocardial perfusion imaging with both mental (public speaking task) and conventional (exercise or pharmacological) stress testing. Overall, 142 (15.9%) patients experienced mental stress–induced myocardial ischemia. After adjusting for demographic factors, medical history, and medication use, patients in the highest tertile of psychological distress score had 35% higher odds of having mental stress–induced ischemia compared to those in the lowest tertile (odds ratio [OR], 1.35 [95% CI, 1.06–2.22]). Stratified analyses showed that the association between psychological distress score and mental stress–induced myocardial ischemia was significantly associated only within the subgroup of patients with a prior myocardial infraction, with patients with a prior myocardial infarction in the highest tertile having a 93% higher odds of developing myocardial ischemia with mental stress (95% CI, 1.07–3.60). There was no significant association between psychological distress and conventional stress–induced ischemia (OR, 1.19 [95% CI, 0.87–1.63]). Conclusions Among patients with a history of myocardial infarction, a higher level of psychosocial distress is associated with mental stress–induced myocardial ischemia but not with ischemia induced by a conventional stress test.