Systems Vaccinology

• Type of Material: Article
• Authors: Bali Pulendran, Emory University; Shuzhao Li, Emory University; Helder Imoto Nakaya, Emory University
• Language: English
• Date: 2010-10-29
• Publisher: Elsevier (Cell Press)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.immuni.2010.10.006
• Title of Journal or Parent Work: Immunity
• ISSN: 1074-7613
• Volume: 33
• Issue: 4
• Start Page: 516
• End Page: 529
• Grant/Funding Information: B.P. thanks the National Institutes of Health and the Bill and Melinda Gates Foundation for their generous support
• Research Categories: Health Sciences, Immunology; Health Sciences, Pathology

Abstract

Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely ignorant of the mechanisms by which successful vaccines stimulate protective immunity. Two recent advances are beginning to illuminate such mechanisms: realization of the pivotal role of the innate immune system in sensing microbes and stimulating adaptive immunity, and advances in systems biology. Recent studies have used systems biology approaches to obtain a global picture of the immune responses to vaccination in humans. This has enabled the identification of early innate signatures that predict the immunogenicity of vaccines, and identification of potentially novel mechanisms of immune regulation. Here we review these advances, and critically examine the potential opportunities and challenges posed by systems biology in vaccine development.