Ethnic differences in the lymphocyte proliferative response induced by a murine IgG1 antibody, Leu-4, to the T3 molecule

• Type of Material: Article
• Authors: Toru Abo, University of Alabama at Birmingham; Arabella Tilden, University of Alabama at Birmingham; Charles M. Balch, University of Alabama at Birmingham; Katsuo Kumagai, Tohoku University; Gary M. Troup, University of New Mexico; Max Cooper, Emory University
• Language: English
• Date: 1984-01-01
• Publisher: Rockefeller University Press
• Publication Version: Final Published Version
• Copyright Statement: © Rockefeller University Press.
• Final Published Version (URL): http://dx.doi.org/10.1084/jem.160.1.303
• Title of Journal or Parent Work: Journal of Experimental Medicine
• ISSN: 0022-1007
• Volume: 160
• Issue: 1
• Start Page: 303
• End Page: 309
• Grant/Funding Information: This work was supported by grants CA-13148, CA-27197, CA-16673, and RR-32 from the National Institutes of Health and by the Medical Research Service of the Veterans Administration.
• Keywords: Research & Experimental Medicine; Life Sciences & Biomedicine; Science & Technology; Immunology
• Research Categories: Biology, Microbiology; Health Sciences, Immunology

Abstract

The mitogenic effects of isotypically diverse antibodies to the T3 molecule were examined in genetically diverse population groups. Whereas the OKT3 antibody (IgG2a) was mitogenic for blood mononuclear cells from all individuals tested, the 38.1 antibody (IgM) was consistently nonmitogenic. In contrast, studies of the mitogenic effects of the Leu-4 antibody (IgG1) revealed striking ethnic differences. More than 80% of Caucasians and Negroes were good Leu-4 responders, whereas most individuals of Asian origin, including Indian, Japanese, and Chinese, were either Leu-4 nonresponders or Leu-4 low responders. However, the majority of American Indians, as well as a significant minority of Chinese, were good responders. Cell separation studies confirmed that monocytes govern the different mitogenic effects of the anti-T3 antibodies. The results reveal interesting ethnik differences in monocyte accessory function probably mediated via the Fc-γ receptor, in the stimulation of T lymphocytes by an IgG1 antibody against the T3 molecule.