Publication

Family history of cancer in benign brain tumor subtypes versus gliomas

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Last modified
  • 05/23/2025
Type of Material
Authors
    Quinn T. Ostrom, Case Western Reserve UniversityChristopher McCulloh, CASE School of MedicineYanwen Chen, CASE School of MedicineKaren Devine, CASE School of MedicineYingli Wolinsky, CASE School of MedicinePerica Davitkov, CASE School of MedicineSarah Robbins, Case Western Reserve UniversityRajesh Cherukuri, CASE School of MedicineAshokkumar Patel, CASE School of MedicineJaime Vengoechea Barrios, Emory University
Language
  • English
Date
  • 2012-12-01
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2012 Ostrom, McCulloh, Chen, Devine, Wolinsky, Davitkov, Robbins, Cherukuri, Patel, Gupta, Cohen, Barrios, Brewer, Schilero, Smolenski, McGraw, Denk, Naska, Laube, Steele, Greene, Kastl, Bell, Aziz, Chiocca, McPherson, Warnick, Barnett, Sloan and Barnholtz-Sloan.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2234-943X
Volume
  • 2
Issue
  • FEB
Start Page
  • 19
End Page
  • 19
Grant/Funding Information
  • National Institute of Health/National Cancer Institute (P30-CA043703 to Yanwen Chen and Jill S. Barnholtz-Sloan, HHSN28 × 273 to Karen Devine, Andrew E. Sloan, and Jill S. Barnholtz-Sloan, HHSN261201000057C to Karen Devine, Yanwen Chen, Mark Cohen, Cathy Brewer, Cathy Schilero, Kathy Smolenski, Frances Laube, Ruth Steele, Susan Bell, Dina Aziz, E. A. Chiocca, Christopher McPherson, Ronald Warnick, Gene H. Barnett, Andrew E. Sloan, and Jill S. Barnholtz-Sloan).
Abstract
  • Purpose: Family history is associated with gliomas, but this association has not been established for benign brain tumors. Using information from newly diagnosed primary brain tumor patients, we describe patterns of family cancer histories in patients with benign brain tumors and compare those to patients with gliomas. Methods: Newly diagnosed primary brain tumor patients were identified as part of the Ohio Brain Tumor Study. Each patient was asked to participate in a telephone interview about personal medical history, family history of cancer, and other exposures. Information was available from 33 acoustic neuroma (65%), 78 meningioma (65%), 49 pituitary adenoma (73.1%), and 152 glioma patients (58.2%). The association between family history of cancer and each subtype was compared with gliomas using unconditional logistic regression models generating odds ratios (ORs) and 95% confidence intervals. Results: There was no significant difference in family history of cancer between patients with glioma and benign subtypes. Conclusion: The results suggest that benign brain tumor may have an association with family history of cancer. More studies are warranted to disentangle the potential genetic and/or environmental causes for these diseases.
Author Notes
  • Correspondence: Quinn T. Ostrom, Department of Anthropology, Case Western Reserve University, Mather Memorial Room 238, 11220 Bellflower Road, Cleveland, OH 44106-5065, USA. e-mail: qto@case.edu
Keywords
Research Categories
  • Health Sciences, Oncology
  • Biology, Genetics

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