Effect of D-ribose supplementation on delayed onset muscle soreness induced by plyometric exercise in college students

• Type of Material: Article
• Authors: Wei Cao, Beijing Sport University; Junqiang Qiu, Beijing Sport University; Tianwei Cai, Beijing Sport University; Longyan Yi, Beijing Sport University; Dan Benardot, Emory University; Menghui Zou, Beijing Sport University
• Language: English
• Date: 2020-08-10
• Publisher: Taylor & Francis Group
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s). 2020
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1186/s12970-020-00371-8
• Title of Journal or Parent Work: Journal of the International Society of Sports Nutrition
• Volume: 17
• Issue: 1
• Start Page: 42
• End Page: 42
• Grant/Funding Information: Funding was provided by the National Key R&D Program of China (2018YFC2000600).
• Keywords: Dietary Supplements; Lower Extremity; Humans; Plyometric Exercise; Oxidative Stress; Male; Muscle soreness; Isokinetic muscle strength; Muscle damage; Muscle Strength; Myalgia; Biomarkers; Ribose; Young Adult; Time Factors; Oxidative stress
• Research Categories: Chemistry, Biochemistry; Health Sciences, Nutrition; Biology, Physiology

Abstract

Objective Previous investigations suggest that appropriate nutritional interventions may reduce delayed onset muscle soreness (DOMS). This study examined the effect of D-ribose supplementation on DOMS induced by plyometric exercise. Methods For the purpose of inducing DOMS, 21 untrained male college students performed a lower-limb plyometric exercise session that involved 7 sets of 20 consecutive frog hops with 90-s of rest between each set. Muscle soreness was measured with a visual analogue scale 1-h before, 24-h after, and 48-h after exercise. Subjects were then randomly placed into the D-ribose group (DRIB, n = 11) and the placebo group (PLAC, n = 10) to assure equivalent BMI and muscle soreness. After a 14-d washout/recovery period, subjects performed the same exercise session, with DRIB ingesting a 200 ml solution containing 15 g D-ribose 1-h before, 1-h, 12-h, 24-h, and 36-h after exercise, and PLAC ingesting a calorically equivalent placebo of the same volume and taste containing sorbitol and β-cyclodextrin. Muscle soreness and isokinetic muscle strength were measured, and venous blood was assessed for markers of muscle damage and oxidative stress 1-h before, 24-h and 48-h after exercise. Results In DRIB, muscle soreness after 24-h and 48-h in the second exercise session were significantly lower (p < 0.01) than was experienced in the first exercise session. In the second exercise, blood-related markers of muscle soreness, including creatine kinase, lactate dehydrogenase (LDH), myoglobin and malondialdehyde (MDA) in DRIB after 24-h were lower in DRIB after 24-h than in PLAC (MDA, p < 0.05; rest outcomes, p < 0.01). In addition, LDH and MDA in DRIB were significantly lower (p < 0.01) after 24-h in DRIB than in PLAC. No difference was found in isokinetic muscle strength and oxidative stress markers, including superoxide dismutase and total antioxidant capacity, between DRIB and PLAC after 24-h and 48-h. Conclusion D-ribose supplementation reduces muscle soreness, improves recovery of muscle damage, and inhibits the formation of lipid peroxides. Young adult males performing plyometric exercise are likely to realize a DOMS reduction through consumption of D-ribose in 15 g/doses both before (1-h) and after (1-h, 12-h, 24-h, 36-h) exercise. These results suggest that appropriately timed consumption of D-ribose may induce a similar alleviation of exercise-induced DOMS in the general public.