Recent progress in translational research on neurovascular and neurodegenerative disorders

• Type of Material: Article
• Authors: Hans-Ulrich Demuth, Fraunhofer-Institut fur Zelltherapie und Immunologie; Rick M. Dijkhuizen, University Medical Center Utrecht; Tracy D. Farr, University of Nottingham; Mathias Gelderblom, Universitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat; Karen Horsburgh, University of Edinburgh; Costantino Iadecola, MIND Research Institute; Damian D. Mcleod, University of Newcastle, Australia; Dominik Michalski, Universitat Leipzig; Tim H. Murphy, The University of British Columbia; Josune Orbe, Universidad de Navarra; Willem M. Otte, University Medical Center Utrecht; Gabor C. Petzold, Deutsches Zentrum fur Neurodegenerative Erkrankungen e.V.; Nikolaus Plesnila, University of Munich Medical Center; Georg Reiser, Otto von Guericke University of Magdeburg; Klaus G. Reymann, Leibniz Institute for Neurobiology; Maria A. Rueger, Uniklinik Koln; Dorothee Saur, Universitat Leipzig; Sean I. Savitz, University of Texas Medical School at Houston; Stephan Schilling, Fraunhofer-Institut fur Zelltherapie und Immunologie; Neil J. Spratt, University of Newcastle, Australia; Renee J. Turner, University of Adelaide; Raghu Vemuganti, University of Wisconsin Madison; Denis Vivien, Universite de Caen Basse Normandie; Manuel Yepes, Emory University; Marietta Zille, Weill Cornell Medical College; Johannes Boltze, Fraunhofer-Einrichtung fur Marine Biotechnologie
• Language: English
• Date: 2017-01-03
• Publisher: IOS Press
• Publication Version: Final Published Version
• Copyright Statement: © 2017 - IOS Press and the authors.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3233/RNN-160690
• Title of Journal or Parent Work: Restorative Neurology and Neuroscience
• ISSN: 0922-6028
• Volume: 35
• Issue: 1
• Start Page: 87
• End Page: 103
• Grant/Funding Information: Particularly, we express our gratitude for generous grants provided by the Deutsche Forschungsgemeinschaft (grant number: BO3518/1-1) and the International Society of Cerebral Blood Flow and Metabolism.
• Keywords: hemorrhage; cerebral ischemia; neuroimmunology; stroke; neuroprotection; dementia experimental therapy; Alzheimer's disease; sex differences; cerebral small vessel disease; translational research; vascular cognitive impairment; in vivo imaging; neurorepair; brain
• Research Categories: Health Sciences, Medicine and Surgery; Biology, Neuroscience

Abstract

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms. This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.