Publication

Recognition of Human Oncogenic Viruses by Host Pattern-Recognition Receptors

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Last modified
  • 02/20/2025
Type of Material
Authors
    Nelson C Di Paolo, Emory University
Language
  • English
Date
  • 2014-07-22
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2014 Di Paolo.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 5
Issue
  • 353
Grant/Funding Information
  • This work was supported by the National Institute of Health (AI065429) and by funding provided by the Children’s Healthcare of Atlanta (CHOA) Research Trust.
Abstract
  • Human oncogenic viruses include Epstein–Barr virus, hepatitis B virus, hepatitis C virus, human papilloma virus, human T-cell lymphotropic virus, Kaposi’s associated sarcoma virus, and Merkel cell polyomavirus. It would be expected that during virus–host interaction, the immune system would recognize these pathogens and eliminate them. However, through evolution, these viruses have developed a number of strategies to avoid such an outcome and successfully establish chronic infections. The persistent nature of the infection caused by these viruses is associated with their oncogenic potential. In this article, we will review the latest information on the interaction between oncogenic viruses and the innate immune system of the host. In particular, we will summarize the available knowledge on the recognition by host pattern-recognition receptors of pathogen-associated molecular patterns present in the incoming viral particle or generated during the virus’ life cycle. We will also review the data on the recognition of cell-derived danger associated molecular patterns generated during the virus infection that may impact the outcome of the host–pathogen interaction and the development cancer.
Author Notes
  • Correspondence: Nelson C. Di Paolo, Lowance Center for Human Immunology, Division of Rheumatology, Departments of Pediatrics and Medicine, Emory University, 1760 Haygood Drive, E269, Atlanta, GA, USA. e-mail: ncdipaolo@emory.edu
Keywords
Research Categories
  • Health Sciences, Oncology
  • Health Sciences, General

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