Basal cell carcinoma and Cyclooxygenase: Translation to the Clinic

• Type of Material: Article
• Authors: Jack Arbiser, Emory University
• Language: English
• Date: 2010-01
• Publisher: American Association for Cancer Research
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: ©2010 American Association for Cancer Research
• Final Published Version (URL): http://cancerpreventionresearch.aacrjournals.org/content/3/1/4
• Title of Journal or Parent Work: Cancer Prevention Research
• ISSN: 1940-6207
• Volume: 3
• Issue: 1
• Start Page: 4
• End Page: 7
• Grant/Funding Information: National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS; J.L. Arbiser was supported by a Veterans Administration Merit Award, NIH grant R01 AR02030, and grants from the Jamie Rabinowitch-Davis Foundation and the Minsk Foundation.
• Research Categories: Health Sciences, Oncology

Abstract

Tang et al demonstrate a pivotal role of the cyclooxygenase (COX) enzyme pathway in the pathogenesis of basal cell carcinoma in mice, with elegant experiments in mice overexpressing COX-1 and COX-2 or in mice deficient in COX-1 and 2 showing an increase or decrease respectively in mice bearing the basal call carcinoma prone patch heterozygote background. They followed the murine findings with a study in humans with loss of patch and found a trend towards decreased tumor burden of BCC in humans. This has implications for public health.