Advanced age a risk factor for illness temporally associated with yellow fever vaccination

• Type of Material: Article
• Authors: Michael Martin, Centers for Disease Control and Prevention; Leisa H. Weld, Centers for Disease Control and Prevention; Theodore F. Tsai, Centers for Disease Control and Prevention; Gina T. Mootrey, Centers for Disease Control and Prevention; Robert T. Chen, Centers for Disease Control and Prevention; Manette Niu, U.S. Food and Drug Administration; Martin S. Cetron, Centers for Disease Control and Prevention; Phyllis E Kozarsky, Emory University
• Language: English
• Date: 2001-11-01
• Publisher: Centers for Disease Control and Prevention
• Publication Version: Final Published Version
• Copyright Statement: Emerging Infectious Diseases is an open access journal published monthly by the Centers for Disease Control and Prevention (CDC).
• Final Published Version (URL): http://dx.doi.org/10.3201/eid0706.010605
• Title of Journal or Parent Work: Emerging Infectious Disease
• ISSN: 1080-6040
• Volume: 7
• Issue: 6
• Start Page: 945
• End Page: 951
• Keywords: ENCEPHALITIS; DISEASE; DECADE; UNITED-STATES; POLIOMYELITIS; Science & Technology; Life Sciences & Biomedicine; Immunology; Infectious Diseases; VIRUS
• Research Categories: Health Sciences, Public Health; Health Sciences, Epidemiology

Abstract

In 1998, the Centers for Disease Control and Prevention was notified of severe illnesses and one death, temporally associated with yellow fever (YF) vaccination, in two elderly U.S. residents. Because the cases were unusual and adverse events following YF vaccination had not been studied, we estimated age-related reporting rates for systemic illness following YF vaccination. We found that the rate of reported adverse events among elderly vaccinees was higher than among vaccinees 25 to 44 years of age. We also found two additional deaths among elderly YF vaccinees. These data signal a potential problem but are not sufficient to reliably estimate incidence rates or to understand potential underlying mechanisms; therefore, enhanced surveillance is needed. YF remains an important cause of severe illness and death, and travel to disease-endemic regions is increasing. For elderly travelers, the risk for severe illness and death due to YF infection should be balanced against the risk for systemic illness due to YF vaccine.