Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

• Type of Material: Article
• Authors: Derek J. Hausenloy, University College London; Jose A. Barrabes, Universitat Autònoma de Barcelona; Hans Erik Botker, Aarhus University Hospital Skejby; Sean M. Davidson, University College London; Fabio Di Lisa, University of Padua; James Downey, University of South Alabama; Thomas Engstrom, Copenhagen University Hospital; Péter Ferdinandy, Semmelweis University; Hector A. Carbrera-Fuentes, Duke-National University of Singapore; Gerd Heusch, University of Essen Medical School; Borja Ibanez, Centro Nacional de Investigaciones Cardiovasculares Carlos III; Efstathios K. Iliodromitis, University of Athens; Javier Inserte, Universitat Autònoma de Barcelona; Robert Jennings, Duke University; Neena Kalia, University of Birmingham; Rajesh Kharbanda, Oxford University Hospitals; Sandrine Lecour, University of Cape Town; Michael Marber, St. Thomas’ Hospital; Tetsuji Miura, Sapporo Medical University; Michel Ovize, Université Claude Bernard; Miguel A. Perez-Pinzon, University of Miami; Hans Michael Piper, Carl von Ossietzky Universität Oldenburg; Karin Przyklenk, Wayne State University; Michael Rahbek Schmidt, Duke-National University of Singapore; Andrew Redington, Cincinnati College of Medicine; Marisol Ruiz-Meana, Universitat Autònoma de Barcelona; Gemma Vilahur, IIB-Hospital Sant Pau; Jakob Vinten-Johansen, Emory University; Derek M. Yellon, University College London; David Garcia-Dorado, Universitat Autònoma de Barcelona
• Language: English
• Date: 2016-11-01
• Publisher: Springer Verlag (Germany)
• Publication Version: Final Published Version
• Copyright Statement: © 2016, The Author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1007/s00395-016-0588-8
• Title of Journal or Parent Work: Basic Research in Cardiology
• ISSN: 0300-8428
• Volume: 111
• Issue: 6
• Start Page: 70
• End Page: 70
• Grant/Funding Information: HACF is funded by a Startup Grant of the “Excellence Cluster Cardio-Pulmonary System” (ECCPS) from the German Research Foundation (DFG, Bonn, Germany) and the “Peter und Traudl Engelhorn-Stiftung” (Weilheim, Germany) and in part by the Russian Government Program for competitive growth of Kazan Federal University, Kazan (Russian Federation).; GH was supported by the German Research Foundation (He 1320/18-3 and SFB 1116/B8).; MRS was funded by Novo-Nordisk Foundation.; TM was funded by the Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research #23591086, #2646113).; DG-D is supported by the Spanish Institute of Health, Instituto de Salud Carlos III (Grants PIE 13/00027, RETICS-RIC, RD12/0042/0021, and PI14/01431).; RS and PF were funded by the European Foundation for the Study of Diabetes (EFSD) New Horizons Collaborative Research Initiative from the European Association for the Study of Diabetes (EASD) and by the European Cooperation in Science and Technology (COST EU-ROS).; DJH was funded by the British Heart Foundation (Grant Number FS/10/039/28270), the Rosetrees Trust, and is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. HEB was funded by the Danish Council for Independent Research (11-108354), the Danish Council for Strategic Research (11-115818), the Novo-Nordisk Foundation and Trygfonden.; PF was funded by the Hungarian Scientific Research Fund (OTKA K 109737 and ANN 107803).
• Keywords: Cardiac & Cardiovascular Systems; PERCUTANEOUS CORONARY INTERVENTION; Cardiovascular System & Cardiology; RISK and SAFE pathway; GLUCAGON-LIKE PEPTIDE-1; Mitochondria; Ischaemic conditioning; GENERATING FREE-RADICALS; ELEVATION MYOCARDIAL-INFARCTION; PERFUSED RABBIT HEART; ARTERY-BYPASS SURGERY; Myocardial reperfusion injury; Cardioprotection; Science & Technology; Life Sciences & Biomedicine; RANDOMIZED CONTROLLED-TRIAL; CARDIAC MAGNETIC-RESONANCE; MITOCHONDRIAL PERMEABILITY TRANSITION; CONTROLLED CLINICAL-TRIAL
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, General

Abstract

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research.