Neurodevelopmental Outcomes Associated with Prefrontal Cortical Deoxygenation in Children with Fetal Alcohol Spectrum Disorders

• Type of Material: Article
• Authors: Julie Kable, Emory University; Claire Coles, Emory University; Sarah N. Mattson, San Diego State University
• Language: English
• Date: 2020-01-10
• Publisher: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: 2020
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1080/87565641.2020.1712604
• Title of Journal or Parent Work: DEVELOPMENTAL NEUROPSYCHOLOGY
• Volume: 45
• Issue: 1
• Start Page: 1
• End Page: 16
• Grant/Funding Information: This research was funded by supported by a grant from the Spray Foundation and by a NIH Research Grant #U01 AA014834 and #U24 AA014811 funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). All or part of this work was done in conjunction with the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), which is funded by grants from the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
• Keywords: Psychology, Experimental; ATTENTION-DEFICIT; ADOLESCENTS; FNIRS; EXPOSURE; Psychology; HEMODYNAMICS; Social Sciences; Psychology, Developmental; BEHAVIOR; NEAR-INFRARED SPECTROSCOPY; WORKING-MEMORY
• Research Categories: Psychology, Developmental; Psychology, Experimental; Psychology, General

Abstract

Relationships between neurodevelopmental functioning and hemodynamic changes in the prefrontal cortex (PFC) were contrasted between children with prenatal alcohol exposure (PAE) and children who differed relative to their history of PAE and the presence of other neurodevelopmental impairment. For all groups, deoxygenated hemoglobin (HBR) levels in the medial PFC area were negatively related to externalizing problems and levels in the medial and right lateral PFC were positively related to errors on a cognitive inhibition task. Hemodynamic changes in the medial and right lateral PFC of children with PAE demonstrated stronger relationships to aspects of executive functioning relative to contrast groups.