Higher mobility scores in patients with cystic fibrosis are associated with better lung function

• Type of Material: Article
• Authors: Aneesha Thobani, Emory University; Jessica A. Alvarez, Emory University; Shaina Blair, Emory University; Kaila Jackson, Emory University; Eric R. Gottlieb, The University of Maryland; Seth Walker, Emory University; Vin Tangpricha, Emory University
• Language: English
• Date: 2015
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2015 AneeshaThobani et al
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1155/2015/423219
• Title of Journal or Parent Work: Pulmonary Medicine
• Volume: 2015
• Start Page: 423219
• End Page: 423219
• Grant/Funding Information: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the paper.; This work was made possible by a student traineeship award from the Cystic Fibrosis Foundation to Aneesha Thobani and in part by grants from the National Institutes of Health Grants UL1 TR000454 (Atlanta Clinical and Translational Science Institute), K23 AR054334 (VT), T32 DK007298, and K01 DK102851 (JAA) and the CF Center grant to Emory University.
• Research Categories: Health Sciences, General

Abstract

Objective. The purpose of this study was to determine whether mobility and physical activity were associated with lung function in adults with cystic fibrosis (CF). Design. This was a prospective cohort observational study in an urban, academic, specialized care center. Participants were ambulatory, nonhospitalized adults with CF. Main Outcome Measures. Mobility was assessed monthly by the Life-Space Assessment (LSA) questionnaire and quarterly by pedometer. Lung function was assessed by spirometry. Results. Twenty-seven subjects participated. Subjects recorded mean pedometer steps of 20,213 ± 11,331 over three days and FEV1% predicted of 77.48% ± 22.60% over one year. The LSA score at enrollment was correlated with initial pedometer steps (r = 0.42 and P = 0.03), and mean LSA score over one year was correlated with mean number of steps (r = 0.51 and P = 0.007). LSA mobility and pedometer scores were correlated with FEV1% predicted at enrollment and throughout the study. Conclusions. Mobility and physical activity measured by LSA questionnaire and pedometer are positively associated with lung function in adults with CF. This study confirms the importance of mobility and physical activity and supports the utility of a simple office-based questionnaire as a measure of mobility in adults with CF.