Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.

• Type of Material: Article
• Authors: Marcin F. Osuchowski, AUVA Research Center; Alfred Ayala, Brown University; Soheyl Bahrami, AUVA Research Center; Michael Bauer, Jena University Hospital; Mihaly Boros, University of Szeged; Jean-Marc Cavaillon, Institut Pasteur; Irshad H. Chaudry, University of Alabama at Birmingham; Craig Coopersmith, Emory University; Clifford S. Deutschman, Northwell Health; Susanne Drechsler, AUVA Research Center; Philip Efron, University of Florida; Claes Frostell, Karolinska Institutet; Gerhard Fritsch, AUVA Trauma Center; Waldemar Gozdzik, Wroclaw Medical University; Judith Hellman, University of California San Francisco; Markus Huber-Lang, University Hospital of Ulm; Shigeaki Inoue, Kobe University; Sylvia Knapp, Medical University Vienna; Andrey V. Kozlov, AUVA Research Center; Claude Libert, Center for Inflammation Research; John C. Marshall, University of Toronto; Lyle L. Moldawer, University of Florida; Peter Radermacher, University Hospital of Ulm; Heinz Redl, AUVA Research Center; Daniel G. Remick, Boston University; Mervyn Singer, University College London; Christoph Thiemermann, Queen Mary University of London; Peter Wang, Feinstein Institute for Medical Research; W. Joost Wiersinga, University of Amsterdam; Xianzhong Xiao, Central South University; Basilia Zingarelli, Cincinnati Children's Hospital Medical Center
• Language: English
• Date: 2018-10
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Final Published Version
• Copyright Statement: © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Shock Society.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1097/SHK.0000000000001212
• Title of Journal or Parent Work: Shock
• ISSN: 1073-2322
• Volume: 50
• Issue: 4
• Start Page: 377
• End Page: 380
• Keywords: infection types; Antimicrobial therapy; experiment; humane modeling; study design; fluid resuscitation; organ dysfunction; guidelines
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Immunology

Abstract

Preclinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of preclinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on preclinical sepsis modeling was held in Vienna in May, 2017. The goal of the conference was to identify limitations of preclinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Preclinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models. A total of 31 experts from 13 countries participated and were divided into six thematic Working Groups: Study Design, Humane modeling, Infection types, Organ failure/dysfunction, Fluid resuscitation, and Antimicrobial therapy endpoints. As basis for the MQTiPSS discussions, the participants conducted a literature review of the 260 most highly cited scientific articles on sepsis models (2002-2013). Overall, the participants reached consensus on 29 points; 20 at "recommendation" and nine at "consideration" strength. This Executive Summary provides a synopsis of the MQTiPSS consensus. We believe that these recommendations and considerations will serve to bring a level of standardization to preclinical models of sepsis and ultimately improve translation of preclinical findings. These guideline points are proposed as "best practices" for animal models of sepsis that should be implemented. To encourage its wide dissemination, this article is freely accessible on the Intensive Care Medicine Experimental and Infection journal websites. In order to encourage its wide dissemination, this article is freely accessible in Shock, Infection, and Intensive Care Medicine Experimental.